| Objective:Thyroid cancer is the fifth most common cancer in women in the USA,and an estimated over 62 000 new casesoccurred in men and women in 2015.The incidence continues to rise worldwide.Differentiated thyroid cancer is the most frequent subtype of thyroid cancer and in most patients,and the standard treatment is effective.Patients with other rare subtypes of thyroid cancer（medullary and anaplastic）are ideally treated by physicians with experiences.But these drugs are not curative and therefore,it is reserved for patients with progressive or symptomatic disease.To investigate the value of Fibronectin 1 in thyroid cancer,the relation between Fibronectin 1 and clinic-pathological situation and to prognosticate the mechanisms involved and to find the new and powerful target for curing the thyroid cancer.Methods:The RNA SEqV2 data and clinical information of Fibronectin 1 in thyroid cancer from the cancer Genome Atlas（TCGA）was downloaded.The comparisons of Fibronectin 1expression between carcinoma samples and non-cancer tissue were performed statistically by the software SPSS.The relationship between Fibronectin 1 and clinic-pathological factors were analyzed by the online tool linkedomics.The gap of the disease free survival was compared by the Kaplan-Meier Plotter.Gene set enrichment analysis（GSEA）was used to predict the gene sets modulated by Fibronectin 1.Results:（1）The mRNA expression of fibronectin 1 was significantly high in thyroid cancer（16.6630±0.3786 vs 12.1824±0.1396,t=11.63,P<0.0001;16.7244±0.1241 vs 12.1824±0.1396,t=24.32,P<0.0001）.（2）High level of fibronectin 1 was showed in papillary thyroid cancer(P=6.197×10-33),advanced T stage(P=3.321×10-8),advanced N stage(P=9.963×10-16)advanced cTNM stage(P=2.780×10-9),more residual cancer(P=7.481×10-3)and associated with poor disease free survival(HR高表达=2;pHR=0.026<0.05).（3）Fibronectin 1 could regulate the gene sets such as NF-κB pathway,PI3K/AKT pathway in TNF signaling,Claudin-1-Notch pathway-EMT in cell adhesion molecules and PAX8/PPARγin thyroid hormone synthesis..Conclusion:（1）FN1 is significantly increased in transcription and expression levels in primary thyroid cancer tissues,leading to poor clinical outcomes.（2）FN1 was inversely associated with recurrence-free survival in thyroid cancer.（3）FN1 is closely related to.NF-κB,PI3K/AKT,Claudin-1-Notch pathway-EMT and PAX8/PPARγpathways.And the mechanisms involved made the FN1 into a power target in thyroid cancer. |
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