Clinical Study On Syndrome Characteristics Of Newly Diagnosed Patients With Lung Adenocarcinoma

Objective: To clarify the constitutional types and distribution characteristics of TCM syndromes in newly diagnosed patients with lung adenocarcinoma,it can provide theoretical basis for clinical diagnosis and treatment of lung adenocarcinoma in TCM,and further improve the therapeutic effect of TCM on lung adenocarcinoma.Method: In this study,we first formulated more than three questionnaires,such as the General Situation Survey Table,the Physical Classification and Judgment Self-Test Table of Traditional Chinese Medicine,and the Questionnaire of Clinical Syndrome Type of Lung Cancer.In the General Situation Survey Table,Including name,age,living habits,smoking history,past history,examination,treatment,TCM symptoms and tongue and pulse.In the Physical Classification and Judgment Self-Test Table of Traditional Chinese Medicine,It includes 9 types of constitution and biased criteria for judging constitution.In the Questionnaire of Clinical Syndrome Type of Lung Cancer,It includes 9 diagnostic criteria of single syndrome type,including five syndrome types of Qi deficiency,Yin deficiency,fire prosperity,Yang deficiency and damp-heat syndrome,and then the syndrome differentiation of zang-fu organs.Before investigation,the patients with Lung adenocarcinoma and squamous cell carcinoma who meet the inclusion criteria in the outpatient or inpatient departments are investigated in the form of on-the-spot questionnaires,and the patients are independently examined and interviewed by special investigators,and if necessary,they can be supplemented by the family members of the patients,and so on.The medical records investigated were reviewed by doctors above the title of primary treatment.Number According to the statistics using Microsoft Excel to establish a database,using SPSS23.0 statistical software,statistical analysis,summed up the new diagnosis of lung adenocarcinoma syndrome characteristics of newly diagnosed patients.Result:1.Pathogenic characteristics of newly diagnosed patients with lung adenocarcinoma: 97 cases of lung adenocarcinoma were collected according to inclusion criteria,including 52 males(53.6%)and 45 females(46.4%).The youngest age of newly diagnosed patients with lung adenocarcinoma was 42 years old,and the oldest was 89 years old,with an average age of 67.07±11.37 years.Thirty-two smokers(33.0%)in lung adenocarcinoma group were smokers.Clinical symptoms: 63 cases(64.9%)had cough,21 cases(21.6%)had hemoptysis,24 cases(24.7%)had dyspnea and 23 cases(23.7%)had weight loss.In the past history of pulmonary tuberculosis and COPD,9 cases(9.3%)and 15 cases(15.5%)of the newly diagnosed pulmonary adenocarcinoma group had a history of pulmonary tuberculosis.2.Distribution and characteristics of TCM constitution types in newly diagnosed patients with lung adenocarcinoma: 31 cases(32.0%),19 cases(19.6%)of Yang deficiency,14 cases(14.4%)of Yin deficiency,10 cases(10.3%)of phlegm-dampness,8 cases(7.2%)of Qi depression,6 cases(6.2%)of placidity,6 cases(6.2%)of blood stasis,2 cases(2.1%)of dampness-heat and 2 cases(2.1%)of special nature.Clinical staging: The biased constitution of early patients is mainly phlegmdampness,Qi-deficiency and yang-deficiency,followed by Yindeficiency and blood-stasis.The biased constitution of late patients is mainly yang-deficiency,Qi-deficiency and yin-deficiency.Characteristics: The constitution types of newly diagnosed patients with lung squamous cell carcinoma were mainly distributed as follows: 29 cases(35.4%)of Qi deficiency,17 cases(20.7%)of Yin deficiency,12 cases(14.6%)of Yang deficiency,9 cases(11.0%)of phlegm-dampness,8 cases(9.8%)of blood stasis,3 cases(3.7%)of qi depression and 2 cases(2.4%)of placidity.Statistically,there are differences between the two groups(P<0.05).3.Distribution and characteristics of TCM syndromes in newly diagnosed patients with lung adenocarcinoma: 28 cases(28.9%)of Yang deficiency syndrome,17 cases(17.5%)of qi deficiency syndrome,16 cases(16.5%)of phlegm-dampness syndrome,10 cases(10.3%)of yin deficiency syndrome,9 cases(9.3%)of qi stagnation syndrome,8 cases(8.2%)of blood stasis syndrome,4 cases(4.1%)of fire excess syndrome,3 cases(3.1%)of phlegm-heat syndrome and 2 cases(2.1%)of dampnessheat syndrome.In clinical staging,phlegm-dampness syndrome,Qi deficiency syndrome,Yang deficiency syndrome and blood stasis syndrome are the most common types of early patients,while Yin deficiency syndrome,Qi deficiency syndrome and Yang deficiency syndrome are the most common types of late patients.Characteristics: The main TCM syndromes of newly diagnosed patients with lung squamous cell carcinoma were Qi deficiency syndrome in 26 cases(31.7%),Yin deficiency syndrome in 12 cases(14.6%),Yang deficiency syndrome in 11 cases(13.4%),Qi stagnation syndrome in 9 cases(11.0%),blood stasis syndrome in 8 cases(9.8%),phlegm-dampness syndrome in 6 cases(7.3%)and fire excess syndrome in 5 cases(6.7%).Statistically,there are differences between the two groups(P<0.05).4.The correlation between TCM constitution and TCM syndromes of newly diagnosed patients with lung adenocarcinoma is as follows: calm constitution,damp-heat constitution,qi-depression constitution and special constitution have nothing to do with TCM clinical syndromes of lung cancer;Qi deficiency syndrome,blood stasis syndrome and Qi stagnation syndrome are mostly characterized by Qi deficiency constitution;Yang deficiency syndrome and phlegm-dampness syndrome are mostly characterized by Yang deficiency constitution;Yin deficiency syndrome and fire prosperity syndrome are mostly characterized by Yang deficiency constitution;Phlegm-dampness syndrome and phlegm-heat syndrome are mostly phlegmdampness constitution,while blood stasis syndrome is mostly blood stasis constitution.Conclusion:There are differences between newly diagnosed patients with lung adenocarcinoma and squamous cell carcinoma in constitution type,distribution and characteristics of TCM syndromes,so clinical treatment should also be different.