Study On The Relationship Between Constitution,Syndrome And APOE Gene Polymorphism In Patients With Acute Ischemic Stroke

[Objective]:By analyzing the distribution of body constitution,syndrome characteristics,Apo E gene polymorphism in patients with acute ischemic stroke,and to explore the relationship between constitution and syndrome,constitution and Apo E gene polymorphism,syndrome and Apo E gene polymorphism,To provide the corresponding clinical research basis for the intervention of patients with acute ischemic stroke from the aspects of constitution,syndrome,and gene.[Method]:This study used a cross-sectional study method of epidemiology and refered to the double diagnostic criteria of Chinese and Western medicine to collect 180 acute ischemic stroke patients from Nanchang in department of encephalopathy of the affiliated Hospital of Jiangxi University of Traditional Chinese Medicine and department of neurology of the second affiliated Hospital of Nanchang University from June 2017 to December 2018 and recorded the patients in general.Demographic data,TCM syndromes,TCM constitution,biological sample information,etc.and finally statistics and analysis are performed on the collected data.[Result]: 1.The total number of patients was 180,the average age was 66.33± 9.28,the maximum was 80 years old,and the youngest was 41 years old;105 males,mean age 66.45±9.03;75 females,mean age 66.17±9.68;the age difference between men and women was not statistically significant(P=0.846>0.05).2.A total of 180 patients with acute ischemic stroke,phlegm-dampness constitution is the most common which susceptible to acute ischemic stroke,a total of 55 cases,followed by 38 cases of static-blood constitution,36 cases of qi deficiency constitution;the most common type of syndrome is wind-phlegm stagnation syndrome,a total of 86 cases,followed by 37 cases of qi deficiency and blood stasis syndrome.3.In patients with phlegm-dampness constitution,static-blood constitution and gentle constitution mostly tend to be wind-phlegm stagnation syndrome in the acute phase of ischemic stroke,qi deficiency constitution is mostly manifested as qi deficiency and blood stasis syndrome,and yin deficiency constitution is manifested in yin deficiency and wind-driven syndrome.4.In patients with acute ischemic stroke,the phlegm-dampness constitution population has the highest proportion of wind-phlegm stagnation syndrome;the qi deficiency constitution in the qi deficiency and blood stasis syndrome is the highest;the yin deficiency constitution is the highest in the yin deficiency and wind-driven syndrome.5.Correlation analysis between constitution and Apo E gene polymorphhism of acute ischemic stroke showed that people with genotype E3/4 were susceptible to phlgm-dampness constitution.6.Correlation analysis between syndrome and Apo E gene polymorphism of acute ischemic stroke showed that there was no significant correlation between different TCM syndromes and Apo E gene polymorphism.7.Correlation analysis of constitution,syndrome,and Apo E gene polymorphism of acute ischemic stroke showed that there was a correlation between phlegm-dampness constitution and wind-phlegm stagnation syndrome,Apo E gene polymorphism and there was no correlation between wind-phlegm stagnation syndrome and Apo E gene polymorphism.There was no significant correlation between other constitutions,syndromes and Apo E gene polymorphisms.[Conclusion]:1.Analysis of the relationship between constitution and syndrome of acute ischemic stroke showed that phlegm-dampness constitution was the main type,followed by static-blood constitution and qi deficiency constitution;the phlegm-dampness constitution was easily expressed as windstagnation syndrome after onset.Qi deficiency was easy to manifest as qi deficiency and blood stasis syndrome.It suggests that different constitution are different in susceptibility to acute ischemic stroke and constitution is the intrinsic factor in determining the syndrome.If the susceptible constitution can be adjusted in advance,the risk of acute ischemic stroke will be reduced,and the effect of “treatment without disease”will be achieved.2.The relationship between constitution and Apo E gene polymorphism in patients with acute ischemic stroke showed that the phlegm-dampness constitution was negatively correlated with E3/E3 and positively correlated with E3/4.No significant correlation was found with ?3 and ?4 alleles.Namely,Apo E genotype is E3/4 type in population that is easy to express phlegm-dampness constitution.It is suggested that carrying the Apo E E3/4 genotype may be the intrinsic basis for the formation of phlgm-dampness constitution,we should perform constitutional regulation of the phlegm-dampness population of the Apo E E3/4 genotype as early as possible to prevent the development of acute ischemic stroke.3.The relationship between syndrome and Apo E gene polymorphism in patients with acute ischemic stroke showed that there was no significant correlation between syndrome and Apo E gene polymorphism.It is suggested that the sample size should be increased in future research work to further study whether the Apo E gene polymorphism is an intrinsic factor and a pathological basis of syndrome formation in acute ischemic stroke.