| Objective Record and explore the relationship between grip strength and cognitive dysfunction of elderly patients in our hospital,and provide a basis for improving grip strength to improve cognitive dysfunction in clinic.Methods 95 patients(aged> 65 years)from September 2015 to December 2015 in the Department of Geriatrics in were retrospectively analyzed.To collect and record the patient's age,education years,body mass index(BMI),grip strength,cognitive function,the underlying disease,blood biochemistry inspection.All the patients were divided to two groups according to standard grip level progression table Grading of men and women: the normal group and grip strength decreased group.Cognitive conditions were evaluated with a variety of neuropsychological scales such as cognition and memory function,executive function,visuospatial ability,language function,attention.The changes in cognitive function between these two groups were assessed by linear correlation analysis and multiple regression analysis.Results 1.There was 95 cases(normal groups: 51 cases;grip strength decreased groups: 44 cases).Compare to the healthy groups,grip strength decreased group had an older age(86.00 ± 3.70,82.51 ± 5.31)and lower BMI(23.24 ± 2.97,24.58 ± 3.00),and there was statistically significant differences(p <0.05),and no statistically significant in sex and education years(p> 0.05).All patients were divided into normal cognitive function group(47 cases)and cognitive decline group(48 patients)according to MMSE ratings.The cognitive decline group had an older age(86.21 ± 4.09,82.00 ± 4.85)and a lower educational years(13.08 ± 4.27,14.87 ± 3.52)than normal group,there was statistically significant differences(p <0.05),and no statistically significant in sex and education years(p> 0.05).2.The average MMSE score was 24.8 ± 4.8 points,the normal group and were 26.3 ± 3.3 min,22.6 ± 5.3 points respectively.The normal group had a higher MMSE score,and there was a significant difference between them(p = 0.000).And normal group had a lower MMSE decline rate than grip strength decreased group(29.4%,75% respectively),the difference was statistically significant(p <0.05).The results of linear correlation analysis showed that there was a significantly correlation between grip strength and MMSE score(R = 0.534,p <0.05).3.There was a higher score in memory function,executive function,visuospatial function,language function area of grip strength decline group(26.7 ± 15.0,33.4 ± 13.7;10.8 ± 5.2,13.1 ± 4.4;5.9 ± 3.5,8,1 ± 2.6;38.5 ± 13.8,48.0 ± 18.9 respectively,and all of them had a significant difference(p <0.05).Difference in attention evaluation area was not statistically significant(p> 0.05).4.Linear correlation analysis and stepwise regression analysis of age,education years,body fat index,serum albumin,hemoglobin,total cholesterol,triglycerides,fasting glucose of total and two grip grouped under MMSE scores were assessed respectively.In general,age,education years,serum albumin had a significant correlation with MMSE score(R=-0.436,0.290 and 0.261 respectively).In the normal group,there was a significant difference in age,education years(R=-0.338,0.340,p <0.05);in grip strength decreased group,there was a significant difference in age,serum albumin(R= 0.370 and-0.340,p<0.05)Conclusions 1.The decreased grip strength in elderly had a high ratio of occurrence of cognitive dysfunction,there was an obvious correlation between decreased grip strength and cognitive dysfunction,and grip strength have a certain appreciable value of cognitive dysfunction.2.The decreased grip strength had an obvious correlation with memory function,executive function,visuospatial function,language function in elderly,but had no significant effect on the assessment of attention.3.Age,education years,serum albumin level are considered as influencing factors,but serum albumin levels had no effect on cognitive dysfunction in normal grip strength. |
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