| Objective: This study is a clinical research on patients of chronic kidney disease(CKD)stage 2-3 treated with Yiqi Wenyang Tongluo Xiezhuo Recipe in order to observe the clinical effects and security as well as provide evidence to clinical application.Methods: 70 cases were selected from the patients of CKD stage 2-3who comply with the trial standards.The 70 cases were randomly divided into two groups which include therapy group and control group.Each group remains 35 cases.The control group was treated by conventional treatment.The therapy group was extra treated with Yiqi Wenyang Tongluo Xiezhuo Recipe.The course of the trial was 6 months.The laboratory indexes(lipid profile,24h-UTP,plasma protein and renal function),clinical effects(the TCM symptoms and the comprehensive effectiveness evaluation of treatment)and security indexes(the rate of adverse reaction,unstable vital signs and significant abnormality in physical indexes,the rate of serious adverse events)of the two groups were observed after 3,6 months of the trial.Finally,the data was summarized and statistical analysis was performed by using SPSS 21.0software.The statistic methods included t-test,rank-sum test and analysis of variance.Results: Finally,62 cases were observed to the end of trial and 8 cases were lost.The 62 cases includes 32 cases of control group and 30 cases of therapy group.1.laboratory indexes(1)lipid profileComparing 3 months after treatment with before treatment,the therapy group's TC,TG and LDL-C were significantly decreased(P < 0.01).The control group's TC and TG were significantly decreased(P<0.01).The controlgroup's LDL-C was decreased(P < 0.05).There was no statistical difference between the two group's indexes which include TC,TG and LDL-C(P>0.05).Comparing 6 months after treatment with before treatment,the therapy group and the control group's TC,TG and LDL-C were significantly decreased(P<0.01).Comparing with the control group,the therapy group's TC was significantly decreased(P<0.01),LDL-C was decreased(P<0.05)and TG was not have statistical difference(P>0.05).Comparing 6 months after treatment with 3 months after treatment,the therapy group indexes which include TC,TG and LDL-C were significantly decreased(P < 0.01).The control group's TC and TG were significantly decreased(P<0.01)as well as LDL-C was decreased(P<0.05).(2)24h-UTPComparing 3 months after treatment with before treatment,the therapy group and the control group's 24h-UTP were significantly decreased(P <0.01).There was no statistical difference between the two groups' s 24h-UTP(P>0.05).Comparing 6 months after treatment with before treatment,the therapy group and the control group's 24h-UTP were significantly decreased(P <0.01).There was no statistical difference between the two groups' s 24h-UTP(P>0.05).Comparing 6 months after treatment with 3 months after treatment,the therapy group and the control group's 24h-UTP were significantly decreased(P<0.01).(3)plasma proteinComparing 3 months after treatment with before treatment,the therapy group's TP and ALB were significantly increased(P < 0.01).The control group's TP was significantly increased(P < 0.01)and ALB was not have statistical difference(P>0.05).There was no statistical difference between the two groups' s TP and ALB(P>0.05).Comparing 6 months after treatment with before treatment,the therapy group and the control group's TP and ALB were significantly increased(P<0.01).Comparing with the control group,the therapy group's ALB was significantly increased(P<0.01)and TP was not has statistical difference(P>0.05).Comparing 6 months after treatment with 3 months after treatment,the therapy group and the control group's TP and ALB were significantly increased(P<0.01).(4)renal functionComparing 3 months after treatment with before treatment,the therapy group's BUN and UA were significantly decreased(P<0.01)as well as CREA was not have statistical difference(P>0.05).The control group's BUN and UA were significantly decreased(P < 0.01)while CREA was significantly increased(P < 0.01).Comparing with the control group,the therapy group's CREA and UA were significantly decreased(P<0.01)as well as BUN was not has statistical difference(P>0.05).Comparing 6 months after treatment with before treatment,the therapy group's BUN,CREA and UA were significantly decreased(P < 0.01).The control group's BUN and UA were significantly decreased(P < 0.01)and CREA was not have statistical difference(P > 0.05).Comparing with the control group,the therapy group's BUN,CREA and UA were significantly decreased(P<0.01).Comparing 6 months after treatment with 3 months after treatment,the therapy group's BUN,CREA and UA were significantly decreased(P <0.01).The control group's BUN was significantly decreased(P<0.01),CREA was decreased(P<0.05)and UA was not has statistical difference(P>0.05).2.clinical effects(1)After treatment for 3 months,the therapy group and the control group'effective rates were 83.3% and 68.8% respectively in terms of the TCM symptoms.And,the therapy group was not superior to the control group(P>0.05).After treatment for 6 months,the therapy group and the control group'effective rates were 90.0% and 81.3% respectively in terms of the TCM symptoms.And,the therapy group was not superior to the control group(P>0.05).(2)After treatment for 3 months,the therapy group and the control group'effective rates were 63.3% and 40.6% respectively in terms of the comprehensive effectiveness evaluation.And,the therapy group was not superior to the control group(P > 0.05).After treatment for 6 months,the therapy group and the control group' effective rates were 76.7% and 46.9%respectively in terms of the comprehensive effectiveness evaluation.And,the therapy group was superior to the control group(P<0.05).3.security indexes(1)The therapy group and the control group' adverse rates were 3.3% and6.3% respectively during the trial.(2)There was no unstable vital signs and significant abnormality in physical indexes during the trial.(3)There was no serious adverse events occur during the trial.Conclusion:1.The clinical effect of Yiqi Wenyang Tongluo Xiezhuo Recipe combined with conventional treatment in the treatment of CKD stage 2-3 can regulate lipids metabolism,decrease urinary protein,increase plasma protein,improve renal function and delay progressive renal damage.2.The clinical effect of Yiqi Wenyang Tongluo Xiezhuo Recipe combined with conventional treatment in the treatment of CKD stage 2-3 can improve the TCM symptoms and comprehensive effectiveness evaluation.3.The clinical effect of Yiqi Wenyang Tongluo Xiezhuo Recipe combined with conventional treatment in the treatment of CKD stage 2-3 is superior to that of conventional treatment.And,the sound effects are increasingly obvious with the prolonged course of treatment.4.The clinical effect of Yiqi Wenyang Tongluo Xiezhuo Recipe combined with conventional treatment in the treatment of CKD stage 2-3 is safe. 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