Expressions And Clinical Significance Of TMPRSS4 And E-cad In Endometrial Carcinoma

Objective:In this study,the expression of TMPRSS4 and E-cad in Endometrial carcinoma tissue were investigated.The correlation between TMPRSS4 and E-cad,as well as the association with pathological grade and clinical staging were also analyzed.Methods:Clinical data of 169 patients with endometrial carcinoma who received surgery as initial treatment in Our hospital from April 2008 to April 2016 were retrospectively investigated.The expressions of TMPRSS4 and E-cad protein on different endometrial carcinoma tissue were examined by immunohistochemistry(SP method),and the percentage of positive cell represented positive rank.SPSS 21.0 software was used for statistical analysis.The patients with EC were followed up for 2 years,and the relationship between prognosis and TMPRSS4,E-cadherin expression were analyzed.Results:1.Of the 169 endometrial carcinoma tissue specimens,the positive expression rate of TMPRSS4 was 63.9%(108/169),but the positive expression rate of TMPRSS4 in 100 normal adjacent mucosa tissue specimens was 12.0%(12/100),TMPRSS4 in endometrial carcinoma tissue was significantly higher than that in normal adjacent mucosa,there was statistical significance between the expression of endometrial carcinoma tissue and normal adjacent mucosa(P<0.001).2.In endometrial carcinoma cancer,the expression of TMPRSS4 has no relation with age and pathological type(P>0.05),but it had great relationships with tumor differentiation,lymph node metastasis and FIGO stages.In 169 cases of endometrial carcinoma,The positive rate(88.9%)of TMPRSS4 in the poorly differentiated group super than High middle differentiation group(59.2%).Thepositive rate of TMPRSS4(87.5%)in lymph node metastasis group super than the No lymph node metastasis group.3.The positive expression rate of E-cad in endometrial carcinoma cancer was 42.6%(72/169).It was significantly lower than that in normal adjacent mucosa,(75.0%,75/100).The differences in both kinds of tissues were statistically significant(P<0.001).4.In endometrial carcinoma cancer,the expression of E-cad has no relation with age and tumor differentiation,and pathological type(P>0.05),but it had relationships with lymph node metastasis and FIGO stages(P<0.774).The positive expression rate of E-cad in endometrial carcinoma cancer with lymph node metastasis(17.5%,7/40)was lower than that in endometrial carcinoma cancer without lymph node metastasis(50.4%,65/129).5.TMPRSS4 and e-cadherin are negatively correlated in endometrial cancer(r = 0.581,P < 0.05).Conclusion:1.TMPRSS4 and E-cad was correlated with endometrial carcinoma pathogenesis,development and differentiation.2.TMPRSS4 and E-cad may involve in endometrial carcinoma genesis and facilitate metastasis3.TMPRSS4 highly expressed in endometrial carcinoma tissue,currently,E-cad is considered as a tumor suppressor.Both of them could be important markers for the progress of endometrial carcinoma.They could be taken as critical determinants of cancer cellular behavior and serve as promising therapeutic targets for endometrial carcinoma cancer.