Research Of Reducing The Pneumothorax In CT-guided Percutaneous Biopsy Of Lung And Mediastinum With Autologous Blood Patch Technique

Objective:The aim of this study is to discuss the feasibility and safety of autologous blood patch technique in decreasing the pneumothorax rate caused by CT-guided percutaneous biopsy of lung and mediastinum.Methods:137 patients with pulmonary and mediastina lesions from the Department of Oncology,the No.401 Hospital of Chinese PLA were selected as the test group(group A),and 112 patients with pulmonary and mediastina lesions were selected from the Department of Thoracic surgery and Respiratory as the control group(group B).Two groups of patients were hospitalized randomly.Group A receiving CT-guided percutaneous biopsy of lung and mediastinum was applied with autologous blood patch technique for closing the visceral pleural and lung wounds.Meanwhile,group B only received CT-guided percutaneous biopsy of lung and mediastinum.The last step analyzed incidence and severity of pneumothorax complications between two groups and the adverse reactions of group A after autologous blood injection.Results:The biopsy of both groups was successful.There was a statistically significant decrease in pneumothorax rate between group A and B [7.30%(10/137)vs.21.43%(24/112);P < 0.05];The incidence of pneumothorax was relative with emphysema and lesion diameter(P<0.05),while the incidence of mild pneumothorax was relative with autologous blood patch technique(P<0.5);After injection with autologous blood patch technique,group A patients had no obvious adverse reactions,except irritating cough and minor hemoptysis.Conclusion:Autologous blood patch technique decreases the incidence rate of pneumothorax induced by CT-guided percutaneous biopsy of lung and mediastinum with high safety.