CT-guided Percutaneous Aspiration Biopsy: Results Of 279 Biopsies

Background and purposeMalignant tumor has become a serious threat to human survival in recent decades. It is difficult to estimate the loss caused by cancer in the world. Therefore, the prevention, diagnosis, treatment for cancer is an important part of medical science. "Early detection and early diagnosis and early treatment" is the key to cancer prevention. With recent advances in medical imaging, the early diagnosis rate of cancer has greatly improved. In recent years, CT-guided percutaneous biopsy is widely accepted as an important procedure for characterizing the cancer with its accurate positioning, high success rate, the high diagnostic accuracy rate, safety and many other advantages. The purpose of this retrospective study was to evaluate the diagnostic accuracy of CT-guided biopsies.Methods279 consecutive CT-guided biopsies performed between December 2008 and March 2010 were analyzed. Both cytomorphology and histopathology were performed in each case. All the procedures were performed by the same radiologist, or by a radiology resident under his supervision. Samples were immediately examined by a cytologist to determine if they were representative. The diagnostic accuracy was assessed by a positive histological result from the operative specimen or based on treatment response and clinical follow-up. Each case was reviewed for complications, including pneumothorax and haemorrhagia, et al.ResultsAdequate samples were obtained in 92.1% of histopathology and 100% of cytomorphology. The accuracy for histopathology was 79.6%. The accuracy for cytomorphology was 81.7%. The overall accuracy in all cases was 93.9%. The complications depend on patient-related conditions, target organ, type of needle used and access route. Minor complications such as local discrete hemorrhage, pain were not rare but are easy to deal with; mild complications such as pneumothorax were rare in lung lesion biopsies and usually did not require drainage; major complications such as severe hemorrhage were rare and may even lead to death. There were only 4 pneumothorax(0.01%),10 haemorrhages.Conclusions:CT-guided percutaneous aspiration biopsy is a safe and effective technique for the diagnosis of lesions in various organs, and the combination of cytomorphology and histopathology has higher sensitivity and accuracy than that when only one examination was performed.