| Objectives The efficacy of ShiJinmo medicine formula on the treatment of type 2 diabetes mellitus(T2DM)and its effect on oxidative stress and circulating miR-375 were observed.This study was aimed to explore the mechanism of its efficacy.Methods Seventy patients with T2 DM who were admitted to the Cangzhou Hospital of Intergrated Traditional Chinese Medicine and Western Medicine from March 2018 to December 2018 were selected.The patients also met the Chinese medicine evidence of lung and stomach stagnation,spleen and kidney deficiency,or turbidity gathering.According to the random number table method,all patients were randomly divided into the control group(35 cases)and the experimental group(35 cases).The patients in the experimental group were given oral administration of ShiJinmo medicine formula(granules),50 ml of warm boiled water,1 dose per day,divided into 3 times,and taken before meals.The patients in the control group received oral metformin enteric-coated tablets,500 mg/time,3 times a day,and taken before meals.The clinical efficacy was evaluated by body mass index,TCM syndrome scores,fasting blood glucose,postprandial 2h blood glucose,glycosylated hemoglobin,fasting insulin release,fasting C-peptide,homeostasis model assessment,total cholesterol,total triglyceride,low-density lipoproteincholesterol,high-density lipoprotein-cholesterol,high-sensitivity C-reactive protein,superoxide dismutase,malondialdehyde,glutathione peroxidase,Catalase,and miR-375.Statistical analysis was performed using SPSS 19.0 statistical software.P<0.05 was considered as statistically significant.Results A total of 70 patients were included in this study.One patient was excluded from the experimental group,one patient was absent from the control group,68 patients were actually completed,34 patients in the experimental group,and 34 patients in the control group.Before treatment,there were no significant differences in baseline data,body mass index,TCM syndrome scores,fasting blood glucose,postprandial 2h blood glucose,glycosylated hemoglobin,fasting C-peptide,homeostasis model assessment,total cholesterol,total triglyceride,low-density lipoprotein-cholesterol,high-density lipoproteincholesterol,high-sensitivity C-reactive protein,superoxide dismutase,malondialdehyde,glutathione peroxidase,Catalase,and miR-375 between in the two groups(P>0.05).After treatment,1.The body mass index of both groups was lower than before treatment(P <0.05),there was no statistical difference between the experimental group and the control group on body mass index(P=0.917);2.The TCM syndrome scores of both groups was lower than before treatment(P<0.05),the TCM syndrome scores in the experimental group were lower than that in the control group(P=0.037);3.The fasting blood glucose,postprandial 2h blood glucose,and glycosylated hemoglobin of both groups were lower than before treatment(P<0.05),the fasting blood glucose,postprandial 2h blood glucose,and glycosylated hemoglobin in the experimental group were lower than that in the control group(P<0.05);4.The fasting C-peptide and homeostasis model assessment of both groups were higher than before treatment(P<0.05),the fasting C-peptide and homeostasis model assessment in the experimental group were higher than that in the control group(P <0.05);5.The total cholesterol,total triglyceride,and low-density lipoprotein-cholesterol of both groups were lower than before treatment(P<0.05),the total cholesterol,total triglyceride,and low-density lipoprotein-cholesterol in the experimental group were lower than that in the control group(P<0.05),the high-density lipoprotein-cholesterol of both groups was higher than before treatment(P<0.05),the high-density lipoprotein-cholesterol in the experimental group was higher than that in the control group(P<0.05);6.The superoxide dismutase and glutathione peroxidase of both groups were higher than before treatment(P<0.05),the superoxide dismutase and glutathione peroxidase in the experimental group were higher than that in the control group(P<0.05).The malondialdehyde of both groups was lower than before treatment(P<0.05),the malondialdehyde in the experimental group was lower than that in the control group(P<0.05).The catalase of both groups was higher than before treatment(P<0.05),there was no statistical difference between the experimental group and the control group on catalase(P=0.053);7.The high-sensitivity C-reactive protein of both groups was lower than before treatment(P<0.05),the high-sensitivity C-reactive protein in the experimental group was lower than that in the control group(P<0.05).8.The miR-375 of both groups was lower than before treatment(P<0.05),the miR-375 in the experimental group was lower than that in the control group(P=0.008).Conclusions 1 ShiJinmo medicine formula can significantly improve the symptoms,and it can control the blood glucase and blood lipid levels in patients with T2 DM.2 ShiJinmo medicine formula can control the inflammatory response,it also can improve oxidative stress and function of islet secretion.3 ShiJinmo medicine formula can improve the islet function,and its mechanism may be related to down-regulating the circulating miR-375 level.Figure 0;Table 18;Reference 152... |
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