| ObjectivesBy measuring the changes of visfatin,blood glucose and lipid levels as well as left ventricular diastolic function in patients with type 2 diabetes mellitus(T2DM)complicated with obesity,the relationship between serum lipid,blood glucose and visfatin levels and left ventricular diastolic function in T2DM patients with obesity was investigated.The relationship between diastolic function and further analysis of the risk factors of T2DM combined with obesity left ventricular diastolic function provide a basis for the prevention and treatment of obese T2DM patients with reduced left ventricular diastolic function.Methods152 patients with type 2 diabetes mellitus admitted to our hospital from October 2017 to October 2018 were divided into left ventricular diastolic dysfunction group(case group)98 cases and normal left ventricular diastolic function group(control group)54 cases according to early left ventricular filling wave(E peak)and late diastolic left atrial systolic wave(E/A peak).Collect general information of selected candidates,history of previous diseases,measure vital signs,record biochemical indicators(liver function,kidney function,blood lipids),blood glucose related metabolic index,visfatin and cardiac ultrasound indicators and calculate BMI,BSA,HOMA-IR,E/A,LVM,LVMI.Questionnaires were conducted to sort out the input data and statistical analysis was performed using SPSS22.0.Results1 There were no significant differences in gender,hypertension,diabetic peripheral vascular disease,diabetic peripheral neuropathy and combined with drinking history between groups by?~2 tests(P>0.05).2 There were significant differences in diabetic microangiopathy and smoking history between groups by?~2 tests(P<0.05).3 The results of independent sample t test showed that there were no significant differences in age,BMI,DBP,FPG,FINS,TC,LDL-C,BUN,AST,ALT and EF between groups(P>0.05).4 The results of independent sample t test showed that there were significant differences in the course of diabetes,SBP,HbA1c,HOMA-IR,TG,HDL-C,UA,CR,GGT and LVMI(P<0.05).5 By t test of independent samples,there was a significant difference in visfatin levels between the groups(P<0.05).The exposure limit was138.04pg/mL,<138.04pg/mL was exposure,and?138.04pg/mL was non-exposure.The chi-square test showed that the risk of decreased left ventricular diastolic function in the exposed patients was 2.5 times of that in the non-exposed patients.6 Regarding whether or not the left ventricular diastolic function was reduced as dependent variable,the indexes with statistical differences were taken as independent variables.The statistical results showed that after controlling for other factors that had an impact on the results,the level of visfatin was still statistically significant.Visfatin was associated with decreased left ventricular diastolic function in T2DM patients with obesity.When visfatin<138.04pg/mL,the risk of decreased left ventricular diastolic function in T2DM patients with obesity increased by 1.72 times.Meanwhile,diabetic microvascular disease,HbA1c,HOMA-IR,TG,CR,GGT and LVMI were associated with decreased left ventricular diastolic function in obese patients with T2DM.7 The ROC curve was used to analyze the diagnostic significance of visfatin and T2DM combined with obesity left ventricular diastolic function.The results showed that the area under the curve of visfatin was 0.665(P<0.05).When visfatin,the largest point of the Jordan index,was 138.38pg/mL as the critical value,its sensitivity was 62.2%,specificity was 64.8%,and Kappa value was 0.252.Conclusions1 The levels of the visfatin was associated with decreased left ventricular diastolic function in T2DM patients with obesity.2 The levels of the visfatin was decreased in T2DM patients with obesity and decreased left ventricular diastolic function.Figure1;Table14;Reference 129. |
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