Systematic Evaluation Of The Application And Efficacy Of Platelet-rich Plasma In Achilles Tendinopathy

Background: At present,there are various treatment methods for achilles tendinopathy,and the clinical effects are different.Platelet-rich plasma,a potential star in biotherapy,is widely used in various fields of medicine.However,the effects of various tendon injuries have been reported to be different.The effect of platelet-rich plasma on Achilles tendinopathy has also been controversial.There are many preclinical studies and retrospective studies in this area,and there is a lack of corresponding systematic evaluation.Objective: To systemically evaluate the efficacy and safety of platelet-rich plasma for Achilles tendinopathy.Methods: The randomized controlled trials about platelet-rich plasma and Achilles tendinopathy were searched in PubMed ? EMbase ? The Cochrane Library?Medline by computer as well as in relevant journals by hand,which were reported before December 2018.Then Meta-analysis was conducted using RevMan 5.3 Software.Results and conclusion: Eight articles and six randomized controlled trials were included,and totally 229 patients were involved,114 cases inthePRP and 115 in the Control group.There was no significant difference in the VISA-A,VAS scores,and recovery of satisfactory exercise between the PRP group and the control group.The available evidence does not adequately support PRP for the treatment of Achilles tendinopathy.Because of sample-size and methodological quality restrictions,this conclusion needs further verification of large-sample,multicenter,and high-quality randomized controlled trials.