Correlation Between Eeg During Aed Withdrawal And Epilepsy Recurrence:A Meta-analysis

Objective: To assess the risk of epilepsy recurrence after withdrawal from antiepileptic drugs(AEDs),researchers extensively studied recurrence-related risk factors,including electroencephalogram(EEG)during AED withdrawal,and they made recurrence prediction models.The correlation between EEG and epilepsy recurrence is controversial.We used meta-analysis to determine the correlation between EEG during AED withdrawal and epilepsy recurrence.Method: A total of seven articles met the criteria for inclusion.The Newcastle-Ottawa Scale was used to conduct the research quality evaluation.Results: A total of 703 patients with epilepsy were included in the study.Patients with abnormal EEGs during withdrawal had a higher recurrence rate than patients with normal EEGs.We also analysed the correlation between EEG alterations and epilepsy recurrence.The results showed that patients with worsening EEGs and unchanged epileptiformEEGs had a higher risk of relapse than patients with consistently normal EEGs.Conclusions: Patients with abnormal EEGs during withdrawal had a higher relapse rate compared to patients with normal EEGs.Abnormal EEGs during withdrawal were a risk factor for recurrence.Patients with worsening EEGs and unchanged epileptiform EEGs had a higher risk of relapse compared to patients with consistently normal EEGs.Worsening EEGs and unchanged epileptiform EEGs appear to be borderline risk factors for recurrence.Significance: Abnormal EEGs during withdrawal were a predictor for relapse.In light of the predictive value of EEGs,EEG recordings should be taken during the reduction of AEDs.