Dynamic Changes And Clinical Significance Of Plasma CC16 In Patients With Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Objective:To observe the dynamic changes of plasma Clara cell secretory protein?CC16?in patients with acute exacerbation of chronic obstructive pulmonary disease?AECOPD?,and to explore its role in the occurrence and development of the disease and clinical significance.Methods:A total of 71 AECOPD patients were included in this study as observation group.All subjects completed the CAT score questionnaire and were sampled 2 ml of venous blood on the first day?T1?,the seventh day?T2?after their admission.And FEV1%pred,FVC%pred,FEV₁/FVC,PaCO₂,WBC,NEUT%,CRP,PCT and the length of stay of subjects were recorded.Another 20 healthy adults were enrolled as the control group.And each subject of the control group were sampled 2ml of venous blood.The plasma CC16 levels of the two groups were tested and compared,and analyzed its correlation with CAT score and length of stay.Results:?1?The plasma CC16 level of AECOPD patients was significantly lower than that of the control group,lung function was significantly lower than that of the healthy control group,WBC and NEUT%were significantly higher than that of the healthy control group,with statistically significant differences?P<0.05?.?2?Compared with T1,the plasma CC16 level,CAT score,PaCO₂,WBC,NEUT%,CRP,PCT concentration of AECOPD T2 patie₄nts were significantly decreased,with statistically significant differences?P<0.05?.?3?The plasma CC16 level of AECOPD patients was negatively correlated with their CAT score?r=-0.704,P<0.001?,and also was negatively correlated with the length of stay?r=-0.351,P=0.003?.Conclusions:CC16 is involved in the development and progression of AECOPD and closely related to the severity and prognosis of the disease.Its dynamic changes can predict the condition changes and evaluate the clinical treatment effect of patients with AECOPD.Combined with common clinical indicators,CC16 can shorten the length of stay of patients.