Variation And Clinical Significance Of 16kDa Clara Cell(CC16) Protein In Patients With Pulmonary Contusion

Objective: To investigate the variation of 16 k Da Clara cell protein(CC16) in patients with pulmonary contusion.To explore function and clinical significance of CC16 in the process of pulmonary contusion from the perspective of molecular biology.Methods: Sixteen cases of healthy control and forty-two patients with pulmonary contusion from October 2013 to October 2014 were selected at the first affiliate hospital,Yijishan Hosptial,of Wannan Medical College.Patients were divided into two experimental groups(group I:n=24, moderate pulmonary contusion.group â…¡ :n=18, severe pulmonary contusion) by CT integral method.Enzyme-linked immunoadsordent assay(ELISA) was used to detect the serum levels of CC16 in the patients with pulmonary contusion within 24 h after the incident and at day 1,3,7 and 14(marked form T1-T5) after treatment.The results were compared with the healthy subjects included as controls.Results: 1. Serum CC16 level in each time point from T1-T5 was higher in the experimental group than the controls, with statistical difference(P<0.01). 2. The difference was significant concerning the levels of CC16 measured within 24 h after contusion and at day 1,3,7 and 14 after patients got treatment(P<0.01),and the levels of CC16 tended to decline. In addition, the serum CC16 levels in each time point from T1-T5 in experimental group â…¡ were somewhat higher than group I,with statistical difference(P<0.01).3. The expression of CC16 in patients with pulmonary contusion were positively correlated with volume of lung injury at T1 and T4(Experimental group I:r s=0.912, P<0.05,r s=0.690,P<0.05.Experimental group â…¡ :r s=0.969,P<0.05,r s=0.609,P<0.05),but there were no relationship between them at T5(Experimental group I:r s=0.317,P>0.05, Experimental groupâ…¡:r s=0.253,P>0.05).Conclusions: Serum CC16 levels are markedly elevated at the early stage of pulmonary contusion and tend to decrease after treatment.Rise of the CC16 levels are associated with the injury degree,for which measurement of the levels may serve as a biomarker for evaluation of the serious condition of this pulmonary contusion.