Analysis Of Clinical Risk Factors For Lymph Node Metastasis In The Cervical Central Region Of Papillary Thyroid Carcinoma

Objective: Due to the lack of accurate preoperative diagnosis methods for central lymph node metastasis(CLNM)of papillary thyroid carcinoma(PTC),it is still controversial whether preventive central lymph node dissection(CLND)should be performed.The purpose of this study is to investigate the clinical risk factors of lymph node metastasis in the central area of neck in papillary thyroid carcinoma,and to provide theoretical basis for central lymph node dissection.Methods: One hundred and forty patients who were performed with central lymph node dissection by The Second Affiliated Hospital of Chongqing medical university and finally confirmed with papillary thyroid carcinoma by pathology were collected from January 1,2016 to May 1,2018.Taking the clinical pathologic factors as independent variables and central lymph node metastasis as the dependent variable,using chi-square test and the binary Logistic regression model to analyze,in order to find the high-risk factors of patients who were found with central lymph node metastasis of papillary thyroid carcinoma.Results: Number of malignant nodules(P = 0.277),with Nodular goiter(P = 0.811),with thyroid benign tumors(P = 0.152),with Hashimoto's disease(P = 0.399),ultrasound indicates hypoechoic(P = 0.174)are no correlation with central lymph node metastasis,but age(P = 0.037),gender(P = 0.008),tumor size(P = 0.004)and ultrasound indicates microcalcification(P = 0.006)are associated with central lymph node metastasis.Age(P=0.016 OR=0.383),gender(P=0.016 OR=3.167),tumor size(P=0.003 OR=3.244),and microcalcification(P=0.006 OR=3.148)are independent risk factors as well.Conclusions: In patients of papillary thyroid carcinoma with central lymph node metastasis(CLNM),microcalcification,tumor size,age and gender were the independent predictive risk factors.Clinical prophylactic central lymph node dissection should fully evaluate every patient's gender,age,tumor size,the presence of microcalcification and other factors.