Clinical Characteristics Of Epstein-Barr Virus Infection In Children's Nervous

Objective : To investigate the clinical characteristics of Epstein-Barr virus(EBV)infection in children's nervous.Methods : We retrospectively analyzed the clinical data and follow-up results of 63 children with neurological damage caused by EBV who were hospitalized in the children's hospital of Chongqing medical university from January 2015 to December 2017.Results : EBV infection of the nervous system occur at any time of the year with no significant seasonal differences.The highest incidence was in the age of 0-4 years old.Fever is the main clinical feature(52/63,82.5%).Fever duration was(8.18 ± 5.23d).The main clinical type were :encephalitis/meningoencephalitis 43 cases(43/63,68.2%),acute myelitis 2 cases(2/63,3.2%),acute disseminated encephalomyelitis(ADEM)2 cases(2/63,3.2%),Guillain-wilkes-barre Syndrome(GBS)13 cases(13/63,20.6%),nervous system damage caused by Epstein-Barr virus-hemophagocytic lymphohistiocytosis(EBV-HLH)2 cases(2/63,3.2%),central nervous system-post-transplant lymphoproliferative disorder(CNS-PTLD)1 case(1/63,1.6%).Anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis can be found in the convalescence of EBV encephalitis.EBV encephalitis/meningitis showed no symptoms of tonsillitis,lymph node enlargement,skin rash,hepatosplenomegaly and other symptoms that EBV infection non-central nervous system.The difference of sequel incidence rate between the antiviral treatment group and non-antiviral treatment group has no statistical significance.Acute motor axonal neuropathy is predominant in GBS caused by EBV.Conclusion : There were significant differences in neurological complications caused by EBV.The prognosis of EBV infection in nervous system is good in general.These illnesses are often self-limiting.A few cases can be left with sequelae.