Relationship Between Glycosylated Hemoglobin Level And Aspirin Resistance In Patients With Acute Cerebral Infarction Complicated With Diabetes Mellitus

Objective: By analyzing the relationship between glycosylated hemoglobin level and aspirin resistance in patients with acute cerebral infarction complicated with diabetes,the effect of routine aspirin on platelet resistance in patients with acute cerebral infarction complicated with diabetes with poor blood glucose control was predicted,and the secondary prevention in patients with cerebral infarction was guided.Methods:From January 2017 to October 2017,a total of 244 patients with acute cerebral infarction who were hospitalized in the east area of the second hospital of hebei medical university were collected.All patients were divided into two groups according to the presence or absence of aspirin resistance,and the risk factors leading to aspirin resistance were analyzed;All diabetic patients were divided into two groups according to the presence or absence of aspirin resistance,and the risk factors leading to aspirin resistance were analyzed;Patients with diabetes were classified according to HbA1c: The differences in the incidence of aspirin resistance between the two groups were compared,respectively,for HbA1 c < 6.5% and HbA1c?6.5%,for HbA1 c < 7% and HbA1c?7%,for HbA1 c < 7.5% and HbA1c?7.5%,for HbA1 c < 8% and HbA1c? 8%.ROC curve was used to evaluate the value of HbA1 c level in predicting aspirin resistance.Results:In patients with acute cerebral infarction complicated with diabetes,there was a statistically significant difference in the content of HbA1 c between the aspirin sensitive group and the aspirin resistant group(P=0.037).The area under the ROC curve of hba1 c predicted aspirin resistance was 0.64,P=0.038,and the 95% confidence interval was(0.526-0.755).There was a statistically significant difference in the incidence of aspirin resistance between the group with HbA1 c < 6.5% and the group with HbA1c?6.5%(P=0.04).Conclusion:Elevated HbA1 c is an independent risk factor for aspirin resistance in patients with acute cerebral infarction complicated with diabetes.HbA1 c can predicts the risk of aspirin resistance.In patients with acute cerebral infarction complicated with diabetes,controlling HbA1 c below 6.5% can significantly reduce the incidence of aspirin resistance,thus allowing patients to benefit more from antiplatelet therapy.