Effects Of Butylphthalide On EGF Expression With Cerebral Ischemia Reperfusion Injury In Rats

Objective:To explore the effects of butylphthalide on EGF expression with cerebral ischemia reperfusion injury in rats.Methods:Healthy male SD rats were randomly divided into 5 groups: sham operation group,the cerebral ischemia reperfusion group,low dose butylphthalide group,middle dose butylphthalide group and high dose butylphthalide group.The effects of butylphthalide on EGF expression with cerebral ischemia reperfusion injury in rats was investigated by making the behavioral score,measuring the cerebral infarction volume with TTC staining,assaying the brain slices with HE staining technology and assessing EGF expression withimmunohistochemistry.Results:Butylphthalide with 20 mg/kg,40 mg/kg and 80 mg/kg dose could decrease the behavior score,reduce cerebral infarction volume,alleviate the brain damage and increase the EGF expression.But the protective effects of butylphthalide with 80mg/kg and 40 mg/kg were more effective than that with 20 mg/kg(P<0.01).There was no significant difference between the 80 mg/kg group and the 40 mg/kg group.Conclusion:Butylphthalide can alleviate cerebral ischemia reperfusion injury and play a protective role in the brain,which may be related to the up-regulation of EGF expression.