Observation On Clinical Efficacy Of Basing On Helicobacter Pylori Eradication In The Treatment Of Bile Reflux Gastritis

Objective:To observe the effect of eradication of Helicobacter pylori and combination of aprazole and compound allantoin with Zhizhukuanzhong on bile reflux gastritis,the symptom scores,total effective rate and adverse reactions were evaluated in the groups of eradication of Helicobacter pylori and non-eradication of Hp,as well as in the groups of eprazole and compound allantoin combined with Zhizhukuanzhong and non-combined Zhizhukuanzhong before and after treatment.Methods:171 Patients who were diagnosed with bile reflux gastritis by gastroscopy in the First Hospital of Shanxi Medical University were detected of Hp by 14C-urea breath test.The Hp positive patients were randomly divided into non-eradication Hp group(iprazole enteric-coated tablets 5mg/ times,2 times / day;compound allantoin tablets 2 tablets/times,3 times/day)and eradication Hp group(Adding amoxicillin and clavulanate potassium dispersible tablets 3 tablets/times,2 times/day and Roxithromycin capsules150mg/ times,2 times / day on the basis of non-eradication of Hp group).Hp-negative patients were randomly divided into two drug combination group(5 mg/time,2 times/day of iprazole enteric-coated tablets;2 tablets of compound allantoin tablets,3 times/day)and triple drug combination group(adding Zhizhukuanzhong capsules 3 capsules/time,3times/day on the basis of the two drug combination groups).At the end of the course of treatment,the symptom scores,total effective rate and adverse reactions of the four groups were evaluated before and after treatment.Results:1.The scores of clinical symptoms such as abdominal pain,abdominal distension,nausea,vomiting,acid regurgitation and anorexia were significantly decreased in the Hp eradication group and the non-eradication Hp group(P < 0.05),and the scores of symptoms in the eradication Hp group were lower than those in the non-eradication Hp group significantly(P < 0.05).2.Compared with non-eradication Hp group,the curative effect of eradication Hp group was significantly improved,the effective rates were 60.00% and 87.10%respectively,the difference was statistically significant(P < 0.05).3.The scores of clinical symptoms such as abdominal pain,abdominal distension,nausea,vomiting,acid regurgitation and anorexia were significantly decreased in the two and triple drug combination group(P < 0.05),and the scores of symptoms in the triple drug combination group were lower than those in the two drug combination group significantly(P < 0.05).4.Compared with the two drug combination group,the curative effect of the triple drug combination group was significantly improved,the effective rates were 64.70% and91.53% respectively,the difference was statistically significantly(P < 0.05).Conclusion:For Hp-positive patients with bile reflux gastritis,the curative effect of eradication of Hp is better than that of non-eradication of Hp;for Hp-negative patients with bile reflux gastritis,the curative effect of eprazole and compound allantoin combined with Zhizhukuanzhong capsules is better than that of non-combined ZhizhuKuanzhong capsules.