Clinical Value Of D-dimer In Chronic Obstructive Pulmonary Disease.

Obj ective:By analyzing and comparing the concentration of D-dimer in patients with chronic obstructive pulmonary disease(COPD)and healthy peoplen to explore the relationship between D-dimer and COPD and its clinical value.Methods:60 cases of COPD patients and 60 cases of acute exacebation of COPD(AECOPD)patients were admitted to First Hospital of Shanxi Medical University from December 2017 to December 2018,and 60 cases of healthy patients in our hospital during the same period were enrolled.The D-dimer of the three groups were collected and compared.D-dimer of AECOPD group were collected at admission and one week after treatment to compare.At the same time,all COPD patients were divided into respiratory failure group and non-respiratory failure group according to the results of blood gas analysis on admission,and the D-dimer levels of the two groups were compared.Results:The levels of D-dimer in COPD patients were higher than that in healthy subjects,especially in AECOPD.D-dimers of AECOPD patients were decreased after treatment.The levels of D-dimer in the respiratory failure group were higher than that in the non-respiratory failure group.In addition,the Ievels of D-dimer were significantly elevated in two patients with AECOPD who were diagnosed with pulmonary thromboembolism(PTE)by CT pulmonary angiography(CTPA).Conclusion:The levels of D-dimer were increased in COPD patients and were significantly increased when they were combined with respiratory failure.D-dimer is a risk factor for the acute attack of COPD and can be used as a laboratory index to evaluate the severity of the COPDu Meanwhile,It also plays a guiding role in the assessment of COPD with thrombotic diseases.