The Expression Of Transmembrane Notch Ligand 4 And MMP9 In Endometrial Polyps And Its Clinical Significance

Objective:Endometrial polyps(EP)is one of the most common endometrial lesions in women.It is a single or multiple benign nodular eminence prominent in the uterine cavity,which is mostly caused by localized hyperplasia of endometrial basal glands and stroma.Endometrial polyps have the possibility of malignant transformation.Endometrial polyps can cause menstrual disorders,postmenopausal vaginal bleeding and infertility and other symptoms,which have seriously affected women's health and quality of life.In recent years,the incidence of endometrial polyps has been increasing year by year.The etiology and pathogenesis of endometrial polyps are still unclear.Studies have shown that the proliferation of local tissues in the endometrium requires the formation of new blood vessels.Therefore,angiogenesis plays an important role in the occurrence and development of endometrial polyps.Recent studies have found that Notch signaling pathway is involved in the regulation of angiogenesis and endometrial development.Notch signal pathway includes ligand,receptor,target gene and so on.Transmembrane Notch ligand 4(DLL4)is a newly discovered important ligand of Notch signaling pathway in recent years.Under normal physiological conditions,DLL4 is mainly present in neovasculogenic endothelial cells,retina,brain and hematopoietic tissues,especially in the high expression state of endothelial cells.DLL4 can exist in various tumor tissues under pathological conditions and is involved in the growth and metastasis of tumors.The role of DLL4 in the regulation of angiogenesis has attracted extensive attention.Matrix metalloproteinases(MMPs)are a family of zinc-dependent proteases that degrade extracellular matrix.MMP9 is an important member of the MMP family and plays an important role in angiogenesis and cell migration.MMP9 was first found to be up-regulated in inflammation and some cancers,and its role in tumor invasion and metastasis is closely related to its promotion of angiogenesis.To investigate the expression of DLL4 and MMP9 in endometrial polyp tissues and explore its clinical significance.Methods:Immunohistochemical SP method was used to detect the expression levels of DLL4 and MMP9 in 50 endometrial polyps and 50 normal endometrial tissues.The positive expression of DLL4 and MMP9 and their correlation were analyzed.Results:The positive expression rates of DLL4 and MMP9 proteins in 50 cases of endometrial polyps were 78% and 80%,respectively.The positive expression rates of DLL4 and MMP9 in 50 normal endometrial tissues were 32% and 36%,respectively.The positive expression rate of DLL4 ? MMP9 in endometrial polyp tissues were significantly higher than that of normal endometrial tissue(P< 0.01).The expressions of DLL4 and MMP9 proteins in perimenopausal endometrial polyps were positively correlated(P< 0.01).Conclusion:The expressions of DLL4 and MMP9 were high in endometrial polyp tissues,and these expressions were positively correlated,both of them have a certain mutual effect on the mechanism of endometrial polyps.Therefore,the study on the expression of DLL4 and MMP9 in endometrial polyps and their correlation is of certain significance for the study of the pathogenesis of endometrial polyps and may also provides a theoretical basis for the clinical treatment of endometrial polyps.