Prognostic Value Of Postoperative Radiotherapy In T_1-2N₁M₀ Triple Negative Breast Cancer Patients Received Modified Radical Mastectomy

Objectives To analyze the effection of clinicopathological features,related molecular markers,as well as presence or absence of post-mastectomy radiotherapy,on the prognosis of patients with T₁-₂N₁M₀ triple negative breast cancer?TNBC?received modified radical mastectomy?MRM?,for providing basis for evaluating and improving the prognosis of TNBC patients.Methods A retrospective analysis was performed on the clinical data of 230 T₁-₂N₁M₀TNBC patients aged 24 to 75 years old who underwent MRM at Tangshan People's Hospital and the Fourth Hospital of Qinhuangdao during the period from January 2013 to December 2015.The patients were followed up for 3 years.Statistical analysis was performed by SPSS19.0 software.Kaplan-Meier and COX proportional hazard regression were performed respectively to conduct univariate and multivariate survival analysis to analyze factors affecting prognosis of T₁-₂N₁M₀ TNBC patients received MRM.Results Univariate survival analysis showed that BMI of patients,histological grade,tumor size,vascular cancer embolus,expression of Ki-67,CK5/6,androgen receptor?AR?,and programmed death ligan-1?PD-L1?,as well as presence or absence of post-mastectomy radiotherapy?PMRT?,could affect 3-year disease-free survival of T₁-₂N₁M₀TNBC patients received MRM.Multivariate survival analysis showed that expression of Ki-67,CK5/6,AR and PD-L1 were independent risk factors affecting prognosis of these patients,while PMRT was an independent protective factor of these patients.Conclusions The pathological type of T₁-₂N₁M₀ TNBC is invasive ductal carcinoma.Expression of Ki-67,CK5/6,AR,and PD-L1,and PMRT were all independent prognostic factors affecting prognosis ofT₁-₂N₁M₀ TNBC patients received MRM.The prognosis and survival of T₁-₂N₁M₀ TNBC patients can be evaluated according to the clinicopathological features and the expression of Ki-67,CK5/6,AR,and PD-L1.PMRT should be performed to improve disease-free survival of these patients.These results provide the oretical supports for choosing clinical treatment regimens,as well as evaluating and improving the prognosis.Figure15;Table4;Reference 154...