Relationship Of Obesity With Thyroid Nodules And Uric Acid From Wangsong Residents In Wuhan

Objective This survey aimed to investigate the prevalence of obesity,thyroid nodules and hyperuricemia from the Wansong community in Wuhan,and to analyze the relationship between body mass index(BMI),body fat percentage(BF%),waist circumference(WC),waist height ratio(WHtR),waist-to-hip ratio(WHR)and thyroid nodules,uric acid(UA).Methods A random cluster sampling method was used to conduct the obesity,thyroid function and morphology-related epidemiological surveys of 1498 permanent residents from Wansong Community in Wuhan from 2010 to 2011,including questionnaires,physical examination,thyroid ultrasound,blood glucose,and blood lipids,uric acid,thyroid stimulating hormone(TSH),urinary iodine(UIC)and other indicators.Binary logistic regression analysis was used to identify the relationship between BMI,BF%,WC,WHtR,WHR and thyroid nodules,uric acid.Result1.The prevalence of overweight in the population was 35.4%,the prevalence of obesity was 11.6%,and the prevalence of overweight and obesity in men was higher than that in women(42.8%vs.30.3%,15.2%vs.9.3%,P<0.001).2.The total prevalence of thyroid nodules in the population was 18.5%,and the prevalence of thyroid nodules in women was higher than that in men(20.5%vs.15.4%,P<0.05).The prevalence of thyroid nodules in the age group<40 years old,40-60 years old group and?60 years old group were 10%,21.0%,33.9%(P<0.001),and the age group correlation coefficient r was 0.217(P<0.05).The age group was positively correlated with the prevalence of thyroid nodules.The prevalence of thyroid nodules increased with each increase in age.3.In the total population,higher waist circumference and excess fat were risk factors of thyroid nodules after adjusting related confounding factors including sex,age,smoking history,education,family history of thyroid disease,systolic blood pressure,diastolic blood pressure,UIC,TSH.higher waist circumference(OR:1.369;95%CI:1.011,1.855;P<0.05),excess body fat(OR:1.687;95%CI:1.243,2.289;P<0.05).4.After adjusting related confounding factors including age,smoking history,education level,family history of thyroid disease,systolic blood pressure,diastolic blood pressure,UIC,TSH,higher waist circumference is a risk factor for thyroid nodules in female(OR:1.472;95%CI:1.002,2.163;P<0.05);male body fat excess is a risk factor for thyroid nodules(OR:2.097;95%CI:1.233,3.566;P<0.05).In the age group?50 years,higher waist circumference was a risk factor for thyroid nodules(OR:1.536;95%CI:1.009,2.338;P<0.05);in the age<50 years old,?50 years old,the body fat excess was risk factors for thyroid nodules(OR:1.632;95%CI:1.009,2.640;P<0.05),(OR:1.730;95%CI:1.156,2.589;P<0.05).5.The total prevalence of hyperuricemia in the population was 9.5%.There was no significant difference in the prevalence of hyperuricemia between different sexes.The prevalence of hyperuricemia increased with age(P<0.05).6.After adjusting confounding factors including age,smoking history,drinking history,systolic blood pressure,diastolic blood pressure,cholesterol,triglyceride,low-density lipoprotein,and fasting blood glucose,higher WC and higher WHtR were risk factors of hyperuricemia.WC(OR:1.028;95%CI:1.002,1.056;P<0.05),WHtR x 10~3(OR:1.004;95%CI:1.001,1.007;P<0.05).7.Increased WC and elevated WHtR in men were risk factors for hyperuricemia,WC(OR:1.036;95%CI:1.004,1.068;P<0.05),WHtR×10~3(OR:1.005;95%CI:1.001,1.010;P<0.05);in women,the increasing of WC,WHtR,BMI,BF%,and WHR was the risk factors of hyperuricemia,WC(OR:1.040;95%CI:1.013,1.067;P<0.05),WHtR×10~3(OR:1.005;95%CI:1.001,1.009;P<0.05),BMI(OR:1.083;95%CI:1.012,1.158;P<0.05),BF%(OR:1.037;95%CI:1.002,1.073;P<0.05),WHR×10~3(OR:1.005;95%CI:1.001,1.009;P<0.05).8.In men,WC was more valuable than WHtR for predicting hyperuricemia,WC(AUC=0.634,P<0.001),WHtR(AUC=0.621;P<0.001);in women,WC was more valuable over other obesity indicators to predict hyperuricemia,WC(AUC=0.643;P<0.001),WHtR(AUC=0.640;P<0.001),WHR(AUC=0.639;P<0.001),BMI(AUC=0.607;P<0.05)),BF%(AUC=0.608;P<0.05).Conclusion The prevalence of thyroid nodules in women is significantly higher than that in men.The prevalence of thyroid nodules is significantly higher in elderly patients.higher waist circumference and excess body fat were independent risk factors for thyroid nodules,so elders,females,and who has higher waist circumference or excess body fat should be screened for thyroid B ultrasound;the elevation of WC is an independent risk factor for hyperuricemia in different genders,and WC predicts hyperuricemia is superior to other obesity indicators in different genders;therefore,we should pay more attention to the health effects of central obesity.