The Relationship Between Serum Cardiac Troponin T Level And Outcome In Insular Lobe Hemorrhage Patients

BackgroundAcute intracerebral hemorrhage refers to the hemorrhage in the non-traumatic spontaneous brain parenchyma with the characteristics of high morbidity,acute onset and high disability.It is an acute and severe disease in the department of neurology,and has become a worldwide public health problem.In recent years,many studies have reported that patients with acute intracerebral hemorrhage often have adverse cardiovascular events,including arrhythmias,myocardial ischemia and acute coronary syndrome,which increase the disability rate and mortality during rehabilitation after acute intracerebral hemorrhage.However,the cause of myocardial injury in most patients with acute intracerebral hemorrhage is not directly caused by coronary ischemia.The hemorrhage site is closely related to the incidence and severity of myocardial injury,and myocardial injury may be one of the poor outcomes of acute intracerebral hemorrhage.ObjectiveTo study the relationship between serum cardiac troponin T(cTnT)level and outcome in insular lobe hemorrhage patients.MethodsOne hundred and fifty acute intracerebral hemorrhage patients admitted to our hospital served as a study group and one hundred and fifty healthy persons undergoing physical examination served as a control group.The patients in study group were further divided into insular lobe hemorrhage group(n=59)and non-insular lobe hemorrhage group(n=91).The serum cTnT levels were measured and changes on ECG were detected in different groups.The patients were followed up for six months,during which their outcome was recorded.ResultsThe serum cTnT level and the rate of changes on ECG were significantly higher in study group than in control group(22.00% vs 0.67%,63.33% vs 13.33%,P<0.01).The serum cTnT level,rate of changes on ECG,incidence of ectopic beat,sinus tachycardia and bradycardia,ST-segment elevation,and prolonged QTc interval were significantly higher in insular lobe hemorrhage group than in non-insular lobe hemorrhage group(P<0.05,P<0.01).The serum cTnT level and incidence of ectopic beat and AF were significantly higher while the incidence of sinus bradycardia and ST-segment elevation was significantly lower in right insular lobe hemorrhage patients than in left insular lobe hemorrhage patients(P<0.05,P<0.01).The death rate was significantly higher in patients with a higher serum cTnT level than in those with a lower serum cTnT level(18.18% vs 3.42%,P<0.05).The incidence of moderate and severe damage was significantly higher while that of mild damage was significantly lower in survived patients with a higher serum cTnT level than in those with a normal serum cTnT level(P<0.01).ConclusionsThe serum cTnT level is elevated in early stage of insular lobe hemorrhage,which is related with the hemorrhage site and its outcome.The serum cTnT level is higher and the outcome is poorer in right insular lobe hemorrhage patients with severe myocardial injury than in left insular lobe hemorrhage patients.