Relative Factors Analysis Of Imatinib Trough Concentration In Chinese Patients With Gastrointestinal Tumor

Objective:Imatinib plasma trough levels(IM C_min)have been reported to have a considerable clinical impact in patients with gastrointestinal stromal tumors?GISTs?.We therefore have investigated the factors affecting IM plasma concentration with GIST in Chinese patients.Methods:IM C_minin in 190 patients with GIST who were taking IM were measured.Results:In patients treated with IM 300?n=16?,400?n=168?and more than 400?500 mg:n=1,600 mg:n=5?mg/d,IM C_minin was 1564.54±596.15,1521.26±610.33 and 2540.31±1298.14 ng/mL,respectively.Of the 168 patients treated with IM 400 mg/d,IM C_minin was significantly lower in male?1353.94±492.89 ng/mL?than female?1680.79±669.03 ng/mL,p<0.01?,and in patients with?1439.60±587.66 ng/mL,?than without?1649.88±620.12 ng/mL?gastrectomy?p=0.033?.High IM C_minin was correlated with low body weight?p=0.004?and low body surface area?p<0.001?.Conclusion:IM C_minin at steady state was significantly associated with body weight and body surface area.Monitoring of IM C_minin might be particularly important for optimal treatment with IM in male and patients who have undergone gastrectomy.