The Efficacy Of Probiotics Supplementation On Anti-Helicobacter Pylori Levofloxacin-based Rescue Therapy:A Meta Analysis

Objective:To assess the efficacy and safety of probiotics supple mentation on anti-Helicobacter pylori levofloxacin-based second-line rescue therapyMethods:All relevant controlled trials(RCT)of probiotics reute ri supplementation on anti-Helicobacter pylori levofloxacin-based sec ond-line therapy published before March 1,2017 were collected by searching Pubmed,Embase,the Cochrane Library,CNKI,VIP,CBM and Wan Fang Data.All subjects were treated with anti-Helicobacte r pylori levofloxacin-based rescue therapy.The experimental group was treated with probiotics at the same time,while the control gro up was treated without probiotics,and the process and the outcome of both groups were followed up.Two researchers used RevMan 52 to perform statistical analysis on the basis of literature screening,data extraction and quality evaluation(PEDro)Results:Six RCTs included 430 patients with probiotics(experi mental group)and 380 patients without probiotics(control group).T he results of Meta-analysis:the PP-analysis results about the rate of Hp eradication of the groups with and without probiotics(OR=2.11,95%CI=1.47-3.02,P<0.0001);the ITT-analysis results about the rate of Hp eradication of the groups with and without probiotics(OR=2.01,95%CI=1.43-2.81,P<0.0001)and the comparative results of ad verse reactions about the two groups(OR=0.63,95%CI=0.40?0.99,P=0.05)were all statistically significantConclusion:The probiotics reuteri supplementation on anti-Helic obacter pylori levofloxacin-based second-line therapy can effectively improve the rate of Hp eradication and reduce the side effects of the drugs.