Furazolidone-containing Quadruple Rescue Regimen For Helicobacter Pylori Infection:a Meta-analysis

OBJECTIVE:Compared with regular quadruple regimen, it aims to evaluate the safety and effect of furazolidone-containing quadruple rescue regimen for Helicobacter pylori (Hp) infection by meta-analysis.METHODS:Pubmed, EMBASE, CNKI,VIP, Wanfang Database and CBM were searched. With the index words:"furazolidone", "Helicobacter pylori or Hp", randomized controlled trials (RCT)concerning furazolidone-containing quadruple rescue regimen for Hp infection were identified. Statistical analysis were performed by RevMan 5.0. Treatment outcome (Hp eradicate rate, the rate of adverse drug reactions) uses the odds ratio (OR) for evaluation index, and calculate the 95% confidence interval (95% CI). Heterogeneity between the studies using chi-square test.RESULTS:Six trials involving 788 patients were included (396 patients were with furazolidone and 392 patients were with regular treatment). Meta-analysis of 6RCTs showed that compared with the conventional treatment, patient with furazolidone has significantly higher Hp eradication rates (ITT:P = 0.05,OR= 1.83,95%CI (1.00,3.42);PP:P=0.004,OR=1.99,95%CI (1.25,3.17)). No significant difference of adverse events was found between 2 groups (P>0.05).CONCLUSION:Compared with regular quadruple regimen, furazolidone-containing quadruple regimen is better in the rescue eradication of Hp. The incidence rate of adverse effects is similar between 2 treatments.