Analysis Of Sever Adverse Event In Pediatric Immune Thrombocytopenia

Objective:To explore the risk factors and prognosis of severe adverse event(SAE)in pediatric immune thrombocytopenia(ITP).Methods:Clinical features,risk factors and prognosis of SAE in pediatric ITP patients whose platelet(PLT)count?20×10~9/L and hospitalized in Children's Hospital of Chongqing Medical University from January 2011 to December 2015 were retrospectively analysized.Results:A total of 1 604 pediatric ITP patients with PLT?20×10~9/L were hospitalized,SAE was diagnosed in 140 patients(8.73%)which were included 138 patients(8.60%)of severe bleeding event(SBE)and 2 patients(0.12%)of severe infection event(SIE),intracranial bleeding was confirmed in 6 patients(0.37%).Hemorrhinia and/or menorrhagia were the most common causes for SBE.There was no significant difference in gender,age,duration of disease and PLT count for patients with SBE.Patients presented with SBE were improved,and 1 patient with SIE died of Pneumocystis Carinii Pneumonia.Conclusion:Hemorrhinia and/or menorrhagia were risk factors for SBE in pediatric ITP patients,and medicine treatment should be administered in such patients.Incidence of SAE,particularly intracranial bleeding was low,and medicine administration was unnecessary in most pediatric ITP patients.And sulfonamide should be given to children requiring long-term glucocorticoid therapy to prevent Pneumocystis carinii infection.