The Role Of Epstein-Barr Virus In Extranodal NK/T-cell Lymphoma(ENKTL)

Extranodal NK/T-cell lymphoma(ENKTL)is a rare,invasive extra nodal non-Hodgkin's lymphoma(NHL)that is commonly associated with Epstein-Barr virus(EBV).ENKTL is the commonest to men with no apparent immunodeficiency in Asia and South America.With the exception of EBV,no environmental or external factors are associated with tumorigenesis.The precise mechanism by which EBV infects NK or T cells and the role of the virus in the pathogenesis of ENKTL has not been fully deciphered.However,many recent discoveries have been identified,including disorders of cell signaling and mutations in tumor suppressor genes,which provide insight into the pathogenesis of ENKTL.Circulating EBV-DNA concentrations correlated positively with disease stage and also exhibited prognostic values in NK/T-cell lymphoma.Quantitative detection of EBV-DNA in plasma is extensively used clinically since it is valuable for monitoring treatment response and evaluating prognosis.Moreover,NK/T cell non-Hodgkin's lymphoma generally has a poor prognosis,and research on its prognostic factors is still ongoing.This article focuses on the dynamic relationship of Epstein-Barr virus and ENKTL,and attempts to provide direction for improving patient outcomes.