Clinical Characteristics Of Heart Failure With Mid-range Ejection Fraction

Objective:To analysis the clinical characteristics of heart failure patients with mid-range ejection fraction(HFmrEF)by retrospective study for improving clinical diagnosis and treatment of HFmrEF.Methods:From January 2015 to January 2016,209 heart failure inpatients were enrolled according to our study criteria in the cardiovascular department of first affiliated hospital of Henan Science and Technology University.All patients were classified three groups by the different left ventricular ejection fraction(LVEF),which were HFpEF group(LVEF?50%),HFmrEF group(LVEF<40%-49%)and HFrEF group(LVEF<40%).These clinical data of the baseline data,aetiology,echo-cardiography and blood biochemical for every one were recorded,analyzed and compared between three groups.All Data was processed by SPSS22.0 statistical software.P<0.05 was considered as the criterion for significant differences in statistics.Results:1.In this study,209 heart failure patients were included,including 53 patients(25.36%)with HFpEF,46 patients(22.01%)with HFmrEF,110 patients(52.63%)with HFrEF.The mean age of HFmrEF group was 71.28±10.81 years old,which was older than that of HFrEF group(P<0.05).There was no significant difference in the sex,smoking,alcohol consumption and so on between the three groups.2.In terms of aetiology,the proportion of coronary disease in HFmrEF group was higher than that in HFpEF group and HFrEF group,but the proportion of hypertension,atrial fibrillation and valvular disease was lower than that of HFrEF group(P<0.05).There was no statistical difference in the ratio of diabetes mellitus and chronic kidney disease among the three groups.3.In laboratory examinations,the levels of BNP,uric acid and mean platelet volume in HFmrEF group were lower than those in HFrEF group(P<0.05).The hemoglobin level in HFmrEF group was higher than that in HFpEF group(P<0.05).4.Echo-cardiography showed that the left ventricular end-diastolic diameter in HFmrEF group was smaller than that in HFrEF group(P<0.05),but there was no significant difference compared with HFpEF group.The left atrial diameter andpulmonary arterial pressure in HFmrEF group were smaller than those in other two groups(P<0.05).The interventricular septal thickness and left ventricular posterior wall thickness in HFmrEF group were smaller than those in HFpEF group(P<0.05).Conclusions:1.HFmrEF patients account for a significant proportion(22.01%)of people with all kinds of heart failure.They are aged and cannot be ignored in clinical practice.2.The aetiology of HFmrEF patients are dominated by coronary artery disease.The proportion of hypertension,atrial fibrillation and valvular heart disease is lower.3.In the echo-cardiographic features,the left ventricular end-diastolic diameter in HFmrEF group was smaller than that in HFrEF group;HFmrEF group had a lower left atrium diameter than others.The heart structure of HFmrEF group was closer to that of HFpEF.