Analysis Of The Effect Of Perioperative Antibacterial Drug Intervention In Thoracic Surgery

Antimicrobial agents are the most widely used class of drugs in clinical application,and their expenditure is also the largest occupation of hospital expenses.At present,the unreasonable application of antimicrobial drugs has become a major problem in the world.It is not only easy to cause the emergence of drug-resistant strains,cause various adverse reactions,increase the economic burden of patients,and even induce the emergence of multidrug-resistant bacteria(MDRS),which seriously threatens human health.Due to the overuse of various medical institutions across the country,including hospitals at all levels,especially community service stations,as well as various township health centers,it not only increases the financial burden of patients,but also leads to the frequent occurrence of adverse antimicrobial drug reactions(ADR)and drug-resistant strains.According to relevant reports,China is currently the world's most serious use of antimicrobial drugs in the country.According to the survey data on the use of antimicrobial agents in grade a hospitals in China's four major cities(Beijing,Shanghai,guangzhou and chengdu),the usage rate of antimicrobial agents,combined use of antimicrobial agents,drug sensitivity tests,and the expenditure of antimicrobial agents all exceeded international standards.With more and more attention paid to the use of antimicrobial agents in China and more and more strict management,and gradually synchronized with the international,the clinical application of antimicrobial agents put forward higher requirements.Patients in thoracic surgery are mostly old age,often accompanied by a variety of basic diseases,and are prone to infection due to big trauma,long time and large amount of blood loss during surgery.The extension of intraoperative one-lung ventilation(OLV)and anesthesia time increases the risk of postoperative infection.For fear of postoperative infection,patients in thoracic surgery after surgery use antibiotics for a long time and have a high level of antibiotics.Therefore,it is of great significance to strengthen the intervention in the application of antibacterial agents,promote the rationalization of the application of antibacterial agents,prevent and control the infection of patients in the perioperative period of thoracic surgery,promote the postoperative recovery of patients,and reduce the pain and economic burden of patients.Objective:To evaluate the intervention effect of antibacterial agents in the perioperative period of thoracic surgery,and to explore the intervention method of the application of antibacterial agents in the perioperative period of thoracic surgery,so as to provide a basis for the management of antibacterial agents in thoracic surgery and provide guidance for clinical rational drug use.Methods:Patients undergoing thoracic surgery from 2015 to 2016 were selected as the control group,and patients undergoing thoracic surgery from 2017 to 2018 were selected as the observation group.Since December 2016,our hospital according to the latest national health plan committee of antimicrobial agents application,combined with the actual situation,formulated the "perioperative application of antimicrobial agents to prevent stipulation",in view of the thoracic surgery perioperative antimicrobial application unreasonable phenomenon has established the corresponding intervention measures,and continued intervention in thoracic surgery.The application of antibacterial drugs in the two groups was evaluated,including the selection of antibacterial drugs,the time of use,the time of use,the dosage,the combined use,etc.,and the postoperative infection rate,postoperative hospitalization time,the cost of antibacterial drugs and the total cost of hospitalization in the two groups were compared.Results:1.There was no statistically significant difference between the two groups in the selection of antimicrobial agents,the dosage,the rational rate of combined use,and the postoperative infection rate(P > 0.05).2.The treatment time and duration of medication in the observation group were significantly higher than those in the control group,and the postoperative hospitalization time and cost of antibacterial drugs were significantly lower than those in the control group,with statistically significant differences(P < 0.05).3.The total hospitalization cost of the observation group was increased compared with that of the control group,and the difference was statistically significant(P < 0.05).Conclusion:1.The intervention measures for the use of antimicrobial agents in thoracic surgery formulated by our hospital are practical and effective,which improve the rationality of the application of antimicrobial agents in thoracic surgery during the perioperative period,significantly reduce the cost of antimicrobial agents in thoracic surgery patients and shorten a certain period of postoperative hospitalization,and do not increase the postoperative infection rate of patients.2.This study explored beneficial management experience and provided effective and powerful evidence for other primary medical institutions to establish and improve relevant systems and policies of rational application of antimicrobial agents.