Chronic gastritis is one of the most common diseases of digestive system,and the clinical manifestations are complex,the course is longer and it is prone to repeated seizures.Modern medicine believes that this disease is mainly associated with helicobacter pylori infection,insufficient gastric motility,bile reflux,increased gastric acid and mental factors and so on.The main treatment is the eradication of HP and symptomatic treatment,but the long-term effect is poor and side effects are large.In traditional Chinese medicine,there is no such disease as "chronic gastritis".According to its clinical manifestation,it is classified as "epigastric pain","distention and fullness","gastric discomfort" and other traditional Chinese medicine categories.Through literature search and the literature related to clinical treatment of chronic gastritis was screened out,and further reading and analysis showed that the overall effect of traditional Chinese medicine on its treatment was more satisfactory than that of western medicine,with fewer side effects.According to the inclusion and exclusion criteria,231 literatures related to the treatment of chronic gastritis with traditional Chinese medicine were screened out.Through further careful reading,it can be seen that most of these literatures are comparative studies on clinical effects and personal experience summary,with various medication,and lack of research on the medication law of this disease.With the help of data mining,this paper analyzes the law of drug use of the prescription,and provides reference for clinical drug use.Objective:To analyze the prescription law of chronic gastritis,in order to provide reference for clinical use of traditional Chinese medicine,so as to improve the clinical cure rate of this disease.Methods:Literature on the treatment of chronic gastritis from the self-built database of Cnki and Wanfang database until June 2017 was searched,and then according to the inclusion and exclusion criteria,231 literatures on the treatment of chronic gastritis with traditional Chinese medicine were finally obtained.First,the prescriptions used in the literature were statistically analyzed.Then,the drug name was normalized,and the Excle table was input.The frequency of drugs,drug categories and each type of drugs in the Excel table was analyzed.SPSS18.0 software was used to analyze the association rules of the first 60 traditional Chinese medicines,as well as Chinese goldthread and dried ginger,fruit of citron or trifoliate orange and lagehead atractylodes,and factor analysis and cluster analysis were respectively performed on the traditional Chinese medicines with the frequency of >10%.Results:According to the statistical results,Liujunzi was used for 85 times,Banxiaxiexin for 28 times,Sinisan for 28 times,Chaihushugansan for 21 times,and Huangqijianzhong for 15 times.A total of 231 articles,296 prescriptions,159 herbs,and a frequency of 3042 were used in this study.Frequency analysis: TCMs with high frequency were obtained the top 15 TCMs were Saute Licorice with Honey(214),White Peony Root(162),White Atractylodes Rhizome(136),Medicnal Changium Root(116),Indian Bread(113),Pinellia Tuber(101),Tangerine Peer(89),Coptis Rhizome(79),Bupleurum Root(79),Bitter Orange(76)and Red Sage Root(73),Stragalus Root(73),Cyperus Tuber(61),Corydalis Tuber(60),Villousamomum Fruit(59);The TCMs in the top 5 were Buyi TCMs(1071),Liqi TCMs(37),Qingre TCMs(304),Huoxuehuayu TCMs(267),and Huashi TCMs(170).Among the Buqi,the Buqi TCMs(655)were the most commonly used,and the Buxue TCMs(215)and the Buyin TCMs(196)were the same,and the Buyang TCMs(2)were the least frequently used.Saute Licorice with Honey(214),White Atractylodes Rhizome(136),Medicnal Changium Root(116),Astragalus Root(73),Chinese Yam(30)were commonly used in Buqi TCMs.Tangerine Peel(89),Bitter Orange(55),Cyperus Tuber(61),Costus Root(57),Szechwan Chinaberry Fruit(32),Finger Citron(32)were commonly used in Liqi TCMs;The commonly used Red Sage Root,Corydalis Tuber,Szechwan Covage Rhizome,Zedoaria,Curcuma Root,Trogopterus Dung in Huoxuehuayu TCMs.Qingre TCMs commonly used Copis Rhizome,Scutellaria Root,Mongolian Dandelion Herb and Spreading Hedvotis Herb.They are often used in medicine for Huashi TCMs,such as Villousamomum Fruit,Magnolia Bark,Rhizoma Atractylodis and Agastache Herb.Analysis of association rules: Under the conditions of support degree of 10%,15%,20% and confidence degree of 80%,stratified extraction treatment CG accounted for the top 60 core drug combinations of traditional Chinese medicine(60,15,8,respectively),and the drug flavors involved were 18,8 and 6,respectively.When the confidence degree is 80% and the support degree is 20%,a total of 8 association rules are generated,and the improvement degree is greater than 1,so it is significant.The six traditional Chinese medicines involved were,Medicnal Changium Root,White Atractylodes Rhizome,Indian Bread,Saute Licorice with Honey,Bupleurum Root,White Peony Root.The 8 drug pairs were Medicnal Changium Root,Indian Bread and White Atractylodes Rhizome;White Peony Root,White Aractylodes Rhizome and Saute Licorice with Honey;Saute Licorice with Honey,Indian Bread and White Atractylodes Rhizome;White Peony Root and Saute Licorice with Honey;Bupleurum Root,White Peony Root;Medicnal Changium Root,Saute Licorice with Honey;White Atractylodes Rhizome,Medicnal Changium Root and Saute Licorice with Honey;Bupleurum Root,Saute Licorice with Honey;Above are commonly used medicine pair.Factor analysis: 10 common factors were obtained by analyzing the TCMs with the frequency of >10%,which were: F1: Coasiai Giehnia Root,Dwarf Lilyturf Tuber,Chinese Angelica Root and Rehmannia Root.F2: Pinellia Tubero,Coptis Rhizome,Dried Ginger,Scutellaria Root;F3: White Atractylodes Rhizome,Medicnal Changium Root,Indian Bread,Chinese Yam;F4: Bupleurum Root,Bitter Orange,Cyperus Tuber,Finger Citron;F5: Tangerine Peel,Villousamomum Fruit,Costus Root;F6: Malt and Hawthorn;F7: Medicnal Changium Root,Red Sage Root,Stragalus Root;F8: Saute Licorice with Honey,White Peony Root,Bupleurum Root,Szechwan Lovage Rhizome;F9: Corydalis Tuber and Szechwan Chinaberry Fruit;F10: Tangerine Peel and Chinese Angelica Root.Cluster analysis: on the basis of factor analysis,7 new prescriptions were obtained,respectively C1: Pinellia Tubero,Coptis Rhizome,Dried Ginger,Scutellaria Root,White Atractylodes Rhizome,Medicnal Changium Root,Indian Bread,Chinese Yam,Malt,Hawthorn,Saute Licorice with Honey,White Peony Root,Bupleurum Root,Szechwan Lovage Rhizome;C2: Coasiai Giehnia Root,Dwarf Lilyturf Tuber,Chinese Angelica Root and Rehmannia Root;C3: Bupleurum Root,Bitter Orange,Cyperus Tuber,Finger Citron;C4: Tangerine Peel,Villousamomum Fruit,Costus Root;C5: Medicnal Changium Root,Red Sage Root,Stragalus Root;C6: Corydalis Tuber and Szechwan Chinaberry Fruit;C7: Tangerine Peel and Chinese Angelica Root.Conclusion:1.The pathogenesis of this disease is based on deficiency of spleen and stomach,qi depression,dampness or dampness or dampness,blood stasis.2.The commonly used prescriptions for chronic gastritis are According to the statistical results,Liujunzi,Banxiaxiexin,Sinisan,Chaihushugansan and Huangqijianzhong.3.The core drugs for chronic gastritis are: Saute Licorice with Honey,White Peony Root,White Atractylodes Rhizome,Medicnal Changium Root,Indian Bread,Pinellia Tuber,Tangerine Peer,Coptis Rhizome,Dried Ginger,Bupleurum Root,Bitter Orange and Red Sage Root,Stragalus Root,Cyperus Tuber,Corydalis Tuber. |