The Effects Of Aerobic Exercise On Oxidative Stress And Cognitive Function In Amphetamine-type Stimulant Users

Objective:To observe the level of oxidative stress in patients with ATS use disorders,and the effects of aerobic exercise on oxidative stress and cognitive function,in addition enrich the theory of aerobic exercise intervention on ATS use disorder.Method:The current study use randomized control method.70 Subjects with ATS use disorders from the drug detoxification and rehabilitation centers in Shanghai were recruited and randomly assigned to an exercise(n=35)or non-exercise group(n=35).Meanwhile 35 healthy controls were also recruited.Non-exercise group was only treated with regular education,such as drug and legal knowledge,entertainment activities.In addition to regular education exercise group also received 12 weeks aerobic exercise training,3 times a week,each time lasted for 40 minutes.The aerobic exercise session included a 5 min warm-up,a 20 min main exercise,and a 5 min cool-down.The cognitive functions of ATS users were assessed at baseline and 12-week follow-ups with Chinese version of CogState Battery.And also the peripheral blood of ATS users and controls were collected during baseline,besides,the ATS users'peripheral bloods were also collected during 6-week and 12-week follow-ups.And the oxidative stress were measured together,included total antioxidative capacity(T-AOC),superoxide dismutase(SOD),catalase(CAT),malondialdehyde(MDA).SPSS 17.0 was used to analyze data.?~2test was used for the categorical variables.Independent t test was used for the continuous variables.Repeated measures analysis of variance was used for follow-up data to explore the difference oxidative stress alterations between exercise group and non-exercise group.Result:1.70 patients with ATS use disorders and 35 healthy controls included this study.The average age of all patients was 34.37,mainly of them were male(76.7%).There were no significant statistical difference in social-demographic characteristics and substance use history between exercise group and non-exercise group(p<0.05).However,there was significant statistical difference in grip strength,and the grip strength of exercise group is higher than non-exercise group(p<0.05).2.In baseline,there was no difference of T-AOC between exercise group and non-exercise group(p>0.05).The SOD activity of exercise group was lower than non-exercise group(14.78±2.43 vs 15.99±3.65,p<0.05),while MDA level(7.27±4.90 vs 4.39±2.35,p<0.05)and CAT activity(0.054±0.020 vs 0.027±0.017,p<0.05)were both higher than non-exercise group(p<0.05).3.MDA was negatively correlated with ISL(r=?0.269,p=0.032),MDA was positively correlated with CPAL(r=0.321,p=0.010),While T-AOC was negatively correlated with OCL(r=?0.285,p=0.022).4.There were no significant correlation between oxidative stress and age,smoking years,drinking years,ATS use at one time,years of ATS using,abstinence duration,VO2max?IPAQ?BMI.However,there was a positive correlation between CAT and MDA(r=0.293,p<0.05).5.After intervention,the alterations of T-AOC and SOD both had no significant statistical difference between exercise group and non-exercise group,the interaction effects of time×group were not significant(p>0.05).However,the alterations of CAT and MDA both had significant statistical difference between two groups.The CAT activity was decreased in non-exercise group,while had no change in exercise group,and exercise group was higher than non-exercise group in 12-week follow-ups(p>0.05).The MDA level were increased in both groups,while the increase extent of non-exercise group was higher than exercise group,the MDA level of non-exercise group was higher than exercise group in 12-week follow-ups(p>0.05).6.After intervention,the alterations of cognitive function had no significant difference between exercise group and non-exercise group,the interaction effects of time×group were not significant(p>0.05).Conclusion:We observed that patients with ATS use disorders had systemic oxidative stress,the extent of oxidative stress aggravated after abstinence,and a 12-week moderate intensity aerobic exercise could mitigate the extent of aggravation without improving the cognitive function significantly.