| Objective: Obsessive-Compulsive disorder(OCD)is a chronic disabling disease,the previous study of obsessive-compulsive disorder mainly focused on the cortex-striatothalamo-cortex(CSTC)circuits.In recent years,the study found that there are abnormal structure and function of brain regions outside CSTC circuits in patients with OCD,especially the cerebellum,it has long been thought to be involved in the regulation of movement and physical balance,but recent studies have shown that the cerebellum can associated with advanced cognitive cortex of the cerebral to participate in cognitive and emotional function.However,the role of the cerebellum in the pathogenesis of OCD and its specific relationship with the symptoms still unclear.Methods: 37 patients with OCD and 47 healthy controls matched as age,gender and education level were enrolled in this study.According to connected with different functional network of the cerebral,the cerebellum is divided into corresponding executive control network,default-mode network,affective-limbic network and motor network functional sub-regions in previous studies.In this study,several seed regions in the corresponding functional sub-regions of cerebellum were selected to explore the altered cerebellar-cerebral functional connectivity in patients with OCD,and the relationship between the altered functional connectivity with clinical symptoms of OCD ware explored.Results: OCD patients showed significantly increased cerebellar-cerebral functional connectivity in emotion processing and motor networks,and extensive altered cerebellar-cerebral connectivity in executive control and default-mode networks.Within the OCD group,decreased functional connectivity in default network seed regions spanning the left cerebellar Crus I and the bilateral orbitofrontal gyrus was positively correlated with symptom severity.Conclusion: Altered functional connectivity between the cerebellum and cerebral networks involved in cognitive-affective processing in patients with OCD provides further evidence for the involvement of the cerebellum in the pathophysiology of OCD,and is consistent with impairment in executive control and emotion regulation in this condition. |
