The Clinical Effects Research Of Acupoint Application Therapy For Stage ? Lung Cancer With Cancer-related Fatigue Symptoms During Chemotherapy

ObjectiveApply acupoint application therapy to inpatients with stage III lung cancer with cancer-related fatigue(CRF)symptoms during chemotherapy,to evaluate the effects of it improving CRF symptoms,sleep quality,anxiety and depression,gastrointestinal symptoms and quality of life,and provide clinical ideas for relieving CRF symptoms in patients with lung cancer during chemotherapy.Moreover,this study can promote the clinical application of acupoint application therapy,and promote the development of the Traditional Chinese Medicine nursing.MethodsIn this randomized controlled clinical trial,according to the inclusion and exclusion criteria of stage III lung cancer with CRF symptoms during chemotherapy,we implement this trail from March 2018 through February 2019,82 patients were screened by random number table method in the Oncology Department of a top three hospital in Chengdu,and were randomized into the experimental group and the control group with 41 cases in each group.Then,the patients in control group were conducted the routine care of CRF,the patients in experimental group were conducted the routine care of CRF combined with acupoint application therapy.The therapy was given once every day from the first day of chemotherapy,consecutively for 21 days.Before the intervention and the intervention on the 3rd?10th?21st day,use the Revised Piper Fatigue Scale(PFS-R)? Hospital Anxiety and Depression Scale(HADS)?Chemotherapy Related Gastrointestinal Symptoms Inwentory(CGISI)?Functional Assessment of Cancer Therapy-lung(FACT-L)to evaluate the patient's CRF symptoms,anxiety and depression,gastrointestinal symptoms,and the quality of life.Before the intervention and the intervention on the 21 st day,use the Pittsburgh Sleep Quality Index(PSQI)to evaluate the patient's sleep quality.ResultsA total of 77 patients completed the trial,including 38 patients in the experimental group(2 patients were excluded,1 patient was lossed),and 39 patients in the control group(1 patient was excluded and 1 patient was lossed).1.PFS-R: The PFS-R total scores and the scores of each dimension in the experimental group on the intervention 3rd,10 th,and 21 st day were lower than those in the control group(P<0.05);The results at each time point showed that the above indicators of the intervention on the 3rd day were higher than those before the intervention(P<0.05),and then decreased,the intervention on the 10 th day were lower than those of before the intervention and the intervention on the 3rd day(P<0.05),the indicators at the 21 st day of intervention were lower than the 10 th of intervention(P<0.05).2.PSQI: Except the dimension of hypnotic,the PSQI total scores and the scores of other dimensions in the experimental group on the intervention 21 st day were lower than those in the control group(P<0.05),and lower than those before the intervention(P<0.05).3.HADS: The scores of anxiety in the experimental group on the intervention 10 th day,21 st day were lower than those in the control group(P<0.05),the HADS total scores and the scores of depression in the experimental group on the intervention 3rd,10 th,and 21 st day were lower than those in the control group(P<0.05);The results at each time point showed that the above indicators of the intervention on the 3rd day were higher than those before the intervention(P<0.05),and then decreased,the intervention on the 10 th day were lower than those of before the intervention and the intervention on the 3rd day(P<0.05),the indicators at the 21 st day of intervention were lower than the 10 th of intervention(P<0.05).4.CGISI: The CGISI total scores and the scores of each dimension in the experimental group on the intervention 3rd,10 th,and 21 st day were lower than those in the control group(P<0.05);The results at each time point showed that the above indicators of the intervention on the 3rd day were higher than those before the intervention(P<0.05),and then decreased,the intervention on the 10 th day were lower than those of before the intervention and the intervention on the 3rd day(P<0.05),the indicators at the 21 st day of intervention were lower than the 10 th of intervention(P<0.05).5.FACT-L: The FACT-L total scores and the scores of each dimension in the experimental group on the intervention 3rd,10 th,and 21 st day were higher lower than those in the control group(P<0.05);The results at each time point showed that the above indicators of the intervention on the 3rd day were lower than those before the intervention(P<0.05),and then increased,the intervention on the 10 th day were higher than those of before the intervention and the intervention on the 3rd day(P<0.05),the indicators at the 21 st day of intervention were higher than the 10 th of intervention(P<0.05).ConclusionThe acupoint application therapy can effectively alleviate CRF symptoms in patients with stage III lung cancer during chemotherapy,and improve their sleep quality,reduce anxiety and depression,improve gastrointestinal symptoms and the quality of life.The acupoint application therapy has the advantages of simple operation,safe and effective,and non-toxic side effects,low price and high patient compliance,and is worthy of being promoted in clinical practice.