Correlation Between TCM Syndromes,Sleep Quality And Sex Hormone Levels In Decreasing Ovarian Reserve Function

Objective:To explore the distribution of TCM syndrome types,sleep quality andrelated pathogenic factors in patients with decreased ovarian reserve,to Understand the relationship between TCM syndrome type,sleep quality and FSH,LH,FSH/LH,E2,analysis of the relationship between sleep quality and DOR,in order to provide a theoretical basis for clinical prevention and diagnosis and treatment of ovarian reserve function decline.Methods:Questionnaire survey of 100 DOR patients who met diagnostic criteria and inclusion criteria and 60 healthy women with regular menstrual patterns and normal sex hormones,fill out the General Information Questionnaire,the TCM Syndrome Questionnaire for Declining Ovarian Reserve Function,and the Pittsburgh Sleep Quality Index Questionnaire(PSQI).TCM syndrome type is dialected according to TCM syndrome differentiation standard under the guidance of two deputy directors or a chief physician.The survey data was entered into the Excel table,and the database was established and analyzed using SPSS 22.0 statistical software.Results:1.There was no significant difference in age,menarche age,BMI,marital status,economic status,education,noise of residence,chemical plant around the place of residence,history of dysmenorrhea,production mode,number of productions,and history of infection between the DOR patients and the control group(P > 0 05).There were significant differences between the two groups in occupational types,irritability,depression,anxiety,stress,history of residence,taked emergency contraception,early maternal history of menopause,history of fallopian tubes and ovarian surgery,history of immune disease,number of pregnancies,and number of abortions(P<0.05).2.The Pittsburgh sleep quality index between the two groups in subjective sleep quality,sleep latency,sleep efficiency,sleep disturbances,and daytime dysfunction(sleepiness and lack of energy)and PSQI total score difference was significant(P<0.01).3.The differences in FSH,LH,FSH/LH,E2 levels between the two groups were extremely significant(P<0.01).4.The level of FSH in DOR patients with PSQI total score?7 was significantly higher than that in patients with < 7(P < 0 05),and the E2 level was lower than <7points,the difference was statistically significant(P<0.05).5.The main TCM syndrome types of DOR were as follows: kidney deficiency and liver stagnation syndrome(43.0%),spleen and kidney yang deficiency syndrome(23.0%),liver and kidney yin deficiency syndrome(20.0%),kidney deficiency and blood stasis syndrome(12.0%),spleen deficiency liver depression Certificate(2.0%);the disease of DOR patients is mainly characterized by deficiency syndrome and deficiency-real inclusion;the menstrual performance of patients with DOR was mainly caused by less menstrual flow and late menstruation,accounting for 50% and35%,respectively,followed by menstrual cycle disorder and menopause,with a proportion of 30.0% and 25.0%.6.The total score of PSQI in patients with DOR of TCM syndrome type was from high to low: liver and kidney yin deficiency syndrome> spleen and kidney yang deficiency syndrome> kidney deficiency and blood stasis syndrome> kidney deficiency liver stagnation syndrome,The patients with liver-kidney yin deficiency syndrome have worse sleep quality and longer sleep time than those with kidney deficiency liver depression syndrome,there was a statistically significant difference between the liver-kidney yin deficiency syndrome and the kidney-deficiency liver-stagnation syndrome in the time of falling asleep and the total score of PSQI(P<0.01),there was significant difference in subjective sleep quality between liver and kidney yin deficiency syndrome and kidney deficiency and blood stasis syndrome(P<0.05).7.There was no significant difference in sex hormone levels between the syndromes of DOR patients(P>0.05).Conclusions:1.The main syndromes of DOR patients are: kidney deficiency liverstagnation syndrome,spleen and kidney yang deficiency syndrome,liver and kidney yin deficiency syndrome,kidney deficiency and blood stasis syndrome,spleen deficiency liver stagnation syndrome,the level of FSH in patients with liver and kidney yin deficiency is higher than other syndromes;the quality of sleep in patients with liver and kidney yin deficiency is worse than other syndromes.2.Poor sleep quality in patients with DOR is mainly characterized by poor sleep quality,late sleep,low sleep efficiency,sleep disturbance,and daytime dysfunction(sleepiness and lack of energy).3.DOR patients with poor sleep quality have lower E2 levels than others.4.Mental occupation,adverse emotions,stress in life and work,taked emergency contraception,multiple pregnancy and repeated abortion,history of fallopian tubes and ovarian surgery,early maternal history of menopause,and immune system diseases may be the influencing factors of DOR.