Systematic Evaluation Of Correlation Between Serum Cystatin C Level And Renal Damage In Neonatal Hyperbilirubinemia

Objective: Systematic evaluation of the correlation between serum cystatin C level and renal damage in neonates with yperbilirubinemia can provide evidence-based evidence for the early detection and treatment of neonatal hyperbilirubin nephropathy.Methods: Relevant literatures on neonatal hyperbilirubinemia and serum cystatin C levels between the time of the database establishment and February 2018 were collected.All included studies were evaluated for quality and analyzed using Rev Man 5.3.Results: Twenty cohort studies were included,including 2446 neonates in the observation group and 1506 neonates in the control group,the observation group was divided into mild group(220.6~256.5?mol/L for bilirubin group),moderate group(256.5~342.2?mol/L for bilirubin group)and severe group(342.2?mol/L for bilirubin group)according to the neonatal serum bilirubin value.Analysis results showed that the cystatin C level in the mild group was higher than that in the control group,and the difference was statistically significant(MD=0.29,95%CI: 0.21~0.38).Urinary inhibition C level higher than the control group,moderate group difference was statistically significant(MD=0.58,95%CI: 0.49~0.67).Level of severe cystain C was higher than that of control group,and the difference was statistically significant(MD=0.93,95%CI: 0.73~1.13).Conclusion: 1.Neonatal hyperbilirubinemia has damage to the kidney,and the change of serum cystatin C level is correlated with renal damage,which can be used as a judgment indicator of renal damage in neonatal hyperbilirubinemia.2.The severity and prognosis of renal damage can be assessed by dynamically monitoring serum cystatin C levels.