The Clinical Significance Of Cardiac Troponin In Hyperbilirubinemia Of Newborn And Its Application In Neonatal Diseases

ObjectiveThe paper is to study the clinical significance of cTn? by measuring the level of cTn? in HBN,newborns with infectious diseases and premature babies.Subjects and Methods1.The subjects includes 180 newborns who were selected from the newborns admitted to Baodi Clinical College of Tianjin Medical University from January,2015 to August,2016.The subjects were divided into three groups: the group of HBN,the group of newborns with infectious diseases and the group of premature babies.Each group consists of 60 subjects.The control group was made up of 60 newborns who were admitted to Baodi Clinical College of Tianjin Medical University during the same period.They were in hospital because of cleft palate or elderly pregnancy or their mothers' abnormal gestation and birth.The newborns in the control group were healthy after the observation in hospital(the babies of cleft palate were complications free).On the day in hospital or next day,those babies' 3-4 m L venous blood in drying tube was tested by adopting the method of CLIA to measure cTn?.Then the differences among the four groups were compared and analyzed.2.I choose 80 newborns with hyperbilirubinemia treated from January,2015 to August,2016 in Baodi Clinical College of Tianjin Medical University as the objects of study and divide them into two groups according to HBN classification criterion—40 newborns with severe hyperbilirubinemia and 40 newborns with mild hyperbilirubinemia.Then,collect venous blood from the two groups and test Cardiac Troponin I by Chemiluminescence Immunoassay.After that,detect the newborns' liver functions including Glutamic-pyruvic Transaminase,Total Protein,Albumin,Total bilirubin and Indirect bilirubin,etc.by Automatic biochemical analyzer.3.I choose 80 newborns with hyperbilirubinemia treated from January,2015 to August,2016 in Baodi Clinical College of Tianjin Medical University as the objects of study and divide them into two groups—40 newborns without hemolytic disease and 40 newborns with hemolytic disease.After that,detect the newborns' liver functions including Glutamic-pyruvic Transaminase,Total Protein,albumin,total bilirubin and indirect bilirubin,etc.by Automatic biochemical analyzer.Results1.There is no statistical difference(P>0.05)among the mature group of hyperbilirubinemia,the mature group of infection,the newborn in premature and the newborn in contrast group.The comparative aspects include gender,day-old,delivery mode and Apgar.However,there is statistical difference(P<0.05),which has significance,lying in the compare of Cardiac Troponin I.2.There is statistic difference(p<0.05)that the detection level of cardiac troponin I in mature Neonatal hyperbilirubinemia is higher than that in mature infection group and newborn in premature.There is no statistical significance(P>0.05)in the cardiac troponin I(cTnl)of newborn in mature infection group and premature.3.There is no statistical difference(P>0.05)in the compared newborn of mild and severe group of the hyperbilirubinemia.The comparative aspects include gender,gestational age,day-old,delivery mode,Amniotic fluid properties,birth weight,height,head circumference and Apgar.There is no statistical significance(P>0.05)lying in the detection level of the newborn which in two group.At the same time,there is no correlation among Total bilirubin,Indirect bilirubin and Cardiac Troponin.4.There is no apparent statistic difference(P>0.05)between non-hemolytic hyperbilirubinemia newborns and hemolytic hyperbilirubinemia newborns in gender,gestational age,day-old,delivery mode,amniotic fluid properties,body weight,body length,head circumference and scores of apger.Besides,there is no apparent statistic difference(P>0.05)in cTn?.Conclution1.Among the influential factors including hyperbilirubinemia,infection,premature delivery,what matters to cTn I is hyperbilirubinemia.2.Hyperbilirubinemia can lead to myocardial damage.But cTn? will not increase with the rise of bilirubin.3.cTn I is influenced by both hemolytic and non-hemolytic hyperbilirubinemia.But there is no difference in influence degree.