The Instance Analysis Of Castleman Disease Combined With C3 Glomerulopathy And Acute Interstitial Nephritis Of Literature Review

Objective:Castleman's disease(CD)is a rare clinically disease,but the rate of detection has increased in recent years.CD can invade multiple systems of the body,especially multicentric CD(MCD),often be secondary to kidney damage.If improper treatment can cause renal failure,It's often accompanied by various autoimmune diseases.Laboratory test and physical imaging examinations lack specificity,and renal biopsy is the gold standard for identifying the cause of kidney damage.When the kidney is involved,it can be expressed in a variety of renal pathological types,and its mechanism is still unclear.There is still a lack of standardized treatment standards,the current treatment methods are mostly derived from the treatment experience of lymphoma,but the prognosis is quite different.In recent years,the introduction of biological agents for the treatment of their pathogenesis has greatly improved the prognosis of the disease.However,more clinical randomized controlled trials are needed to assess the safety and efficacy of various drugs and to develop standardized treatment strategies for different clinical severity.Secondary renal damage is a common complication of Castleman's disease,especially as TAFRO syndrome.However,most of them are clinically diagnosed.There are relatively few confirmed by renal biopsy.This article analyzes patients with Castleman's disease associated with renal impairment Experience in medical treatment,emphasizing the importance of renal biopsy for a clear diagnosis of the disease,and Try to explore the possible mechanisms by which it causes kidney damage.Methods: One case was selected from the Department of Nephrology,Fourth Hospital of Hebei Medical University.Clinical medical records of patients with C3 nephropathy and acute interstitial nephritis Review the relevant literature at home and abroad,summarizing the relationship between Castlemman's disease and renal damage Incidence,etiology,pathogenesis,clinical manifestations,pathological features and treatment options In order to diagnose,treat and prognose patients with Castlemman's disease complicated with renal damage Evaluation helps.Result: In this case,patients with Castlemman's disease with renal impairment underwent ultrasound-guided renal biopsy and cervical lymph node biopsy.Further immunohistochemistry confirmed C3 nephropathy in patients with Castlemman's disease.Conclusion: When there is renal damage in patients with Castlemman's disease,it should be paid attention to by clinicians.If necessary,a renal biopsy should be performed to confirm the diagnosis and provide assistance for subsequent treatment.