Clinicopathological Analysis Of Occult Metastasis Of Cervical Lymph Nodes In Early Tongue Squamous Cell Carcinoma

Objective: Through retrospective analysis of 145 cases of clinical cases,the occult metastasis of cervical lymph nodes in early tongue squamous cell carcinoma(cT1-2N0)and its influencing factors were explored,which provided a clinical basis for the treatment of cervical squamous cell carcinoma in the early stage.Methods: A total of 145 cases of early tongue squamous cell carcinoma(cT1-2N0)patients who were admitted to the Oral and Maxillofacial Surgery Department of the Fourth Hospital of Hebei Medical University between January 2011 and January 2018 were collected.All the patients underwent primary tumor resection and cervical lymph node dissection.The postoperative pathology confirmed upper Tongue squamous cell carcinoma.SPSS21.0 statistical software was used to analyze the clinical and pathological factors related to cervical lymph node metastasis by Chi-square/Fisher test.The difference was statistically significant at P<0.05.Result: The occult lymph node metastasis rate of 145 cases of early tongue squamous cell carcinoma was 20.0%.Univariate statistical analysis showed that cervical metastasis of early tongue squamous cell carcinoma(cT1-2N0)was significantly associated with pathological differentiation and the depth of tumor invasion(P<0.05),with sex,age,primary tumor location,the size of the primary tumor and growth pattern had no significant correlation(P>0.05).Conclusions:1.Early squamous cell carcinoma of the tongue(cT1-2N0)was significantly associated with pathological differentiation and the depth of tumor invasion.Patients with early tongue squamous cell carcinoma with moderately poorly differentiated or invading the muscular layer should undergo selective neck dissection(I-III area)at the same time,and the degree of differentiation is highly differentiated or invasive deep in the mucosal layer.Department can be observed mainly,close follow-up.2.For patients with early lingual squamous cell carcinoma with lesions located in the 1/3 or T1N0 phase of the tongue,primary resection is feasible and the neck should be closely observed.3.The occult metastasis of the early tongue squamous cell carcinoma(cT1-2N0)was not related to sex,age,primary tumor location,the size of the primary tumor and growth pattern.