Changes And Significance Of Body Mass Index In 12,145 Patients With Chronic Kidney Disease In Southern Hebei

Objective:Analyzes of the changes in body mass index(BMI)of 12145 patients with chronic kidney disease(CKD)in southern Hebei in the past 9 years,and the relationships between BMI and pathological types,blood pressure,urinary protein,uric acid,and renal function.Methods:To collect the clinical data,pathological data and laboratory-related indicators of 12,145 patients with CKD who were admitted to the Department of Nephrology,Second Hospital of Hebei Medical University from January 2010 to December 2018 and who underwent renal biopsy.All data were analyzed by SPSS22.0 statistical software.Results:1.Clinical features1)12,145 patients with CKD,including 6,762 males(55.7%)and 5,383 females(44.3%),with a male: female ratio of 1.26:1.The age of renal biopsy ranged from 2 to 91 years,with an average age of renal biopsy was 42.72±16.20 years old.In this study,there were 698 cases of children with CKD,accounting for 5.7%,9286 cases of adults,accounting for 76.5%,and 2161 cases of the elderly,accounting for 17.8%.The proportion of adults is higher than that of children and the elderly.The proportion of males in different age stages(children,adults and the elderly)was higher than that of females.The distribution of different genders in different age groups was statistically significant(P<0.05).2)The distribution of body mass index(BMI)in 12145 patients with CKD was statistically significant((P<0.05).From 2010 to 2018,body mass index(BMI)showed an increasing trend.3)The number of CKD patients increased from 2010 to 2018;According to body mass index,12,145 patients with CKD were divided into low weight group,normal weight group,overweight group and obesity group.The proportion of CKD patients in low body weight and the normal weight group decreased year by year with the increase of years,and the difference was statistically significant(P<0.05).The proportion of CKD patients in the obesity group increased with the increase of years,and the difference was statistically significant(P<0.05).2.Blood pressure and body mass index1)There were statistically significant differences in the distribution of systolic and diastolic blood pressure among 12145 CKD patients in each year(P<0.05),and the overall systolic and diastolic blood pressure showed an upward trend from 2010 to 2018.2)In the same year,the mean values of systolic and diastolic blood pressure in the overweight and obesity groups were significantly higher than those in other groups,with statistically significant differences(P<0.05).Both systolic and diastolic blood pressure increased with the increase of body mass index.3.Pathological types and body mass index1)The membranous nephropathy was the most common type in 12,145 patients with CKD,accounting for 42.7%.Secondly,IgA nephropathy 13.3%,glomerular micropathy 11.0%,hepatitis B virus associated nephritis 7.3%,lupus nephritis 3.5%,purpura nephritis 3.1%,hypertension renal damage 3.0%,diabetic nephropathy 3.0%,focal segmental glomerulosclerosis 2.2%,obesity-related nephropathy 0.4%,the other pathological types accounted for 10.5%.In this study,the correlation between pathological types and BMI was investigated in 10,999 patients with CKD,and the pathological types with less than 100 cases were not discussed(except for obesity-related nephropathy).2)The mean body mass index of all pathological types was from small to large,followed by lupus nephritis,purpura nephritis,interstitial nephritis,glomerular micropathy,IgA nephropathy,hepatitis B virus-associated nephritis,membranous nephropathy,focal segmental glomerulosclerosis,diabetic nephropathy,hypertension renal damage,and obesity-related nephropathy.3)IgA nephropathy,membranous nephropathy,hypertensive renal damage,with lupus nephritis,purpura nephritis,hepatitis B virus associated glomerulonephritis,glomerular micropathy,focal segmental glomerular sclerosis,diabetic nephropathy,interstitial nephritis,obesity-related nephropathy difference between body mass index in different years were statistically significant(P<0.05),The body mass index of IgA nephropathy,membranous nephropathy,hypertensive renal damage,purpura nephritis,lupus nephritis and glomerular micropathy,showed an increasing trend;Compared to other pathological types,the mean BMI of lupus nephritis was lower in different years.In the same year,except for obesity-related nephropathy,the mean body mass index of hypertensive renal damage was higher than other pathological types,and the difference was statistically significant(P<0.05).4.The correlation between body mass index and clinical indicatorsBody mass index was negatively correlated with HDL(P<0.05).Body mass index was positively correlated with urinary protein,creatinine,albumin,uric acid,fasting blood glucose,triglycerides,total cholesterol,and lowdensity lipoprotein(p<0.05).Conclusion:1.12145 patients with CKD showed an increasing trend of body mass index year by year.2.The blood pressure of CKD patients increased with the increase of body mass index.3.Different pathological types were correlated with body mass index.4.Body mass index was positively correlated with urinary protein,creatinine,albumin,uric acid,fasting blood glucose,triglycerides,total cholesterol,and low-density lipoprotein,and negatively correlated with highdensity lipoprotein.