Study On The Correlation Between DCE-MRI Quantitative Parameters And Histopathological Differentiation And T Stage Of Rectal Cancer

Objective:To investigate the relationship between quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging and histopathological classification and T stage of rectal cancer.Methods:The imaging data of 54 patients with rectal adenocarcinoma diagnosed in our hospital from February 2017 to December 2018 were retrospectively analyzed.All patients underwent DCE-MRI with 3.0T conventional sequence of rectal MRI.The patients ranged in age from 36 to 87years,with an average age of 70 years,including 31 males and 23 females.Among 54 rectal adenocarcinoma patients,there were 8 highly differentiated adenocarcinoma,35 moderately differentiated adenocarcinoma and 11 poorly differentiated adenocarcinoma;2 cases in T1 stage,13 cases in T2 stage,32cases in T3 stage and 7 cases in T4 stage.K^trans,v_e and k_ep values were measured using MR AW46 post-processing workstation of GE Company.The relationship between K^trans,v_e and k_ep values of DCE-MRI quantitative parameters and the degree of histopathological differentiation and T stage of tumors was analyzed.Results:1.In different pathological T stages of rectal cancer,the K^trans and v_e values had significant difference（P<0.05）,and with the increase of pathological T stages of rectal cancer,the K^trans and v_e values showed a gradual upward trend.There was no significant difference in k_ep value（P>0.05）.2.In the differentiation degree of different pathological tissues of rectal cancer,there was significant difference in K^trans value（P<0.05）,but no significant difference in v_e and k_ep value（P>0.05）.Conclusions:1.The K^trans value of DCE-MRI quantitative parameter is correlated with the degree of differentiation of pathological tissue and T stage.The K^trans value can provide valuable reference for the diagnosis and treatment of rectal cancer.2.The quantitative parameter v_e of DCE-MRI was correlated with T stage,but not with the degree of histopathological differentiation.3.The k_epp value of DCE-MRI quantitative parameter was not related to the degree of histological differentiation and T stage.