| Objective:This article will systematically review the effects of benzodiazepines on the pathogenesis of Alzheimer's disease,To provide evidence-based medicine for the treatment and prevention of Alzheimer's disease.Methods:We have searched three English databases,including Pub Med,Embase,the Cochrane Library database.The keywords included Alzheimer's disease and benzodiazepines,which were linked to the word "OR" in the same category,and "AND" in the different categories.The publication time of retrieval documents is limited from the establishment of the database to July 2018.Because the number of Chinese documents is very small,we limit the retrieval language category to English.All published studies on the effects of benzodiazepines on the pathogenesis of Alzheimer's disease were searched at the same time.One step to find the relevant references to ensure that the literature is complete.According to the standards of inclusion and exclusion,we select the documents that accord with our research criteria,and extract the data.Then the results of the study were analyzed and charted by Meta with Revman5.0 software.Results:A total of 7 articles were included in this paper.7 articles were of high quality English and published between 2009 and 2018.The total number of patients with AD was 235934,and the study population was distributed in many European regions.According to the age,sex and duration of exposure,the study was conducted.The longest follow-up time is 15 years,and the quality of the article is reliable.In the end,our Meta analysis showed that the use of benzodiazepines increased the risk of developing AD(RD=0.05,95%CI:0.03~0.08;P<0.05,I2=96%),with a statistically significant difference.There was no significant difference between the treatment time of benzodiazepine and AD for 90 days(RR=0.80,95%CI:0.65~0.98;P=0.03<0.05,I2=87%),and there was no significant difference between the treatment group and the control group.When used for 90 hours for 180 days,it was also compared with the control group(RR=1.16,95%CI:0.98~1.38;P=0.09>0.05,I2=0).There is no significant difference.When benzodiazepines were used for more than 180 days,the risk of Alzheimer's was significantly higher than those without benzodiazepines.(RR=1.60,95%CI:1.41~1.82;P=0.04<0.05,I2=75%).The difference between the use of benzodiazepines and the risk of AD in different ages,and whether benzodiazepines were used in the 77-80-year-old group There was no significant difference in the risk of AD.(RR=1.00,95%CI:0.94~1.06;P=1.00>0.05,I2=0%).There was no significant difference in the 81-85 year group(RR =1.00,95% CI: 0.94-1.06;P = 1.00> 0.05,I2= 0%);among the groups above the age of 86,the population with benzodiazepines was used,The risk of AD was not significantly higher than those without benzodiazepines(RR=0.99,95%CI:0.92~1.06;P=0.82>0.05,I2=0%).There was no significant difference in the incidence of AD between men and women using benzodiazepines(RD=0.00,95%CI:-0.01~0.01;P=0.99>0.05,I2=0%).Conclusion:The use of benzodiazepines increases the risk of Alzheimer's disease,and the long-term use of benzodiazepines(more than 180 days)has a higher risk of Alzheimer's disease than non-benzodiazepines users,However,because the sample size of our studyis relatively small,and there is no grouping study of drug dosage,the above conclusions need more large samples,and the high-quality research is further confirmed. |
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