Effects Of Occupational (Nursing) Sleep Deprivation On Cognitive Function And Neurotransmitters

Objective:1.Initially explore the effects of long-term,repeated sleep deprivation on cognitive function in the elderly during the middle-aged period caused by occupational factors;2.To Further explore the correlation between sleep deprivation,cognitive function and serum levels of lipids,melatonin,blood sugar and other indicators.Methods:The whole group selected nurses who retired from January 1st,1987 to January 1st,2017 in a top three general hospital in Shanxi Province,and finally included 107 people.Using a one-on-one interview,the self-made general situation questionnaire was used to record their participation value.The number of years of night work and the frequency of night shifts are used to assess the degree of sleep deprivation.Divided into sleep deprivation group(N=82)and non-sleep deprivation group(N=25),through the Mini-mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA)),Clock Drawing Test(CDT),Activity of Daily Living(ADL)assessment,using variance analysis to compare the relationship between different factors and cognition;using multi-factor logistic regression analysis to discuss sleep deprivation The influence of molecular level of hematology and its relationship with cognition,such as melatonin,5-HT,low density lipoprotein(LDL),triglyceride(TG),cholesterol(TC).Results:1.According to the stratification of basic factors,analysis of variance showed that ADL scores of elderly,BMI,hypertension and sleep aids had statistical differences(P<0.05).There was no significant difference among all basic factors in the scores of MMSE,MoCA and CDT(P>0.05).2.After adjusting the influence of age,BMI,hypertension and so on,the scores of cognitive scale in sleep deprivation group were significantly lower than those in non-sleep deprivation group(P<0.05).Comparing the cognitive domains,it was found that the cognitive scores of orientation,attention and calculation,recall and renaming in sleep deprivation group were lower(P<0.05).3.The levels of TC,LDL and melatonin were higher in sleep deprivation group,while the levels of 5-HT were lower(P<0.05),while there were no significant differences in other indicators,including TG,HDL and blood sugar.The intra-group comparison of neurotransmitter levels showed that 5-HT in moderate,severe group was significantly different from that in mild group;melatonin levels in mild,moderate and severe group were different,sleep deprivation was deepened,and melatonin levels gradually increased.4.Logistic regression analysis showed that sleep deprivation was a risk factor for MMSE and MoCA;LDL was a risk factor for MoCA and CDT;5-HT was a protective factor for MMSE and MoCA,and was a risk factor for ADL(OR=1.018,95%CI: 1.007-1.092);melatonin was a risk factor for CDT(OR=1.012,95% CI: 1.002-1.022).Conclusion:1.Occupational(nursing)personnel have long-term,repeated sleep deprivation in the middle-aged period,which is a risk factor for cognitive function in the elderly,mainly characterized by damage in orientation,attention and computing power.2.The effects of long-term and repeated sleep deprivation on cognitive function in the elderly may be related to the changes of LDL,melatonin and 5-HT levels.