Impact Of The Number Of Oocytes Retrieved And The Different Age Groups On The Clinical Outcome Of IVF/ICSI During Long Protocols Controlled Ovarian Hyperstimulation

Objective:To explore the effect of the number of oocytes retrieved and the different age groups on the clinical outcome of IVF/ICSI during long protocols controlled ovarian hyperstimulation.Methods:A total of 1763 IVF/ICSI cycles from July 2011 to July 2016 in Reproductive Medicine Center of the First Hospital of Shanxi Medical College were retrospectively analyzed.Patients were divided into two groups according to clinical outcomes :live birth and no live birth.Patients were divided into four groups according to female age:<25 years old,25-29 years old,30-34 years old and ?35 years old.In addition,patients were divided into five groups according to the number of oocytes retrieved:1 to 5 oocytes,6 to10 oocytes,11 to 15 oocytes,16 to 20 oocytes and more than 20 oocytes.The characteristic and laboratory indexes and main clinical outcomes were compared.Results:(1)Females in the live-birth group are younger than those in the non-live-birth group,with shorter infertility years,lower basic FSH and less total Gn.However,the serum estradiol level on HCG day,egg number,egg maturity rate,fertilization rate,available embryo rate and high-quality embryo rate in the live-birth group are significantly higher than those in the non-live-birth group.(2)Comparisons among different age groups: The total amount of Gn required increased with the increase of age,the fertilization rate was the lowest in the age group <25 years old,the available embryo rate was the highest in the age group of 30-34 years old,the basic FSH in the age group(>35 years old)was significantly higher than that in the age group(<35 years old),and the serum estradiol level on HCG day,the number of eggs harvested,the rate of high-quality embryos,the live rate of fresh transplantation and the cumulative live rate were significantly lower than groups aged less than 35 years old;(3)Comparisons among different numbers of eggs obtained: the age,basic FSH and total Gn required in groups with the number of eggs obtained less than 10 were higher than those in groups with the number of eggs obtained more than 16,but the serum estradiol level on HCG day,fresh transplantation live rate and cumulative live rate were lower,and the fresh transplantation live rate and cumulative live rate were the highest in groups with the number of eggs obtained more than 21;(4)The cumulative lire birth rate was increasing with following the number of oocytes retrieved.Conclusion:(1)Age is an important factor affecting the outcome of IVF/ICSI pregnancy,too young or too old all affect the outcome of IVF/ICSI pregnancy.(2)The number of eggs harvested is another important factor affecting the pregnancy outcome of IVF/IVSI.In a certain range,the pregnancy outcome of IVF/ICSI increases with the increase of the number of eggs harvested.(3)The optimum number of eggs needed to achieve satisfactory pregnancy outcomes in different age groups is different.(4)The cumulative pregnancy rate is an important index to evaluate the pregnancy outcome of IVF/ICSI.