Analysis Of Clinical Outcome Of Routine ICSI And Short-term Fertilization Failure Combined With Early Rescue ICSI In Assisted Reproductive Technology

Objective:To explore the clinical value of short-term fertilization failure combined with early rescue intracytoplasmic sperm injection(ICSI).Methods:The medical records of 540 couples who received IVF or ICSI assisted pregnancy for the first time in the Reproductive Center of the First Hospital of Shanxi Medical University from January 2012 to October 2016 were retrospectively analyzed,and were divided into two groups according to the implementation of early rescue ICSI.The 76 cycles in study group were short-term fertilization failure combined with early rescue ICSI cycles,and the 464 cycles in control group were routine ICSI cycles.The fertilization rate,cleavage rate,high quality embryo rate,rate of frozen embryos,embryo implantation rate,clinical pregnancy rate,miscarriage rate and birth status of the newborn were compared between the two groups.Results:The fertilization rate,polyspermy rate and high quality embryo rate were higher in study group than in control group(85.28% vs 71.23%,6.57% vs 1.58%,38.74% vs 30.74%,P<0.05).There was no significant difference in the cleavage rate,available embryo rate,rate of frozen embryos,cycle cancellation rate and embryo implantation rate between the two groups(P>0.05).There was no significant difference in the biochemical pregnancy rate,clinical pregnancy rate,rate of ectopic pregnancy,early miscarriage rate,late miscarriage rate,preterm birth rate,live birth rate,twin birth rate,low birth weight baby rate,and neonatal gestational age between the two groups(P>0.05).Conclusion:Short-term fertilization failure combined with early rescue ICSI can achieve a high rate of fertilization and embryo quality,prevent the occurrence of fertilization failure,and ameliorate the clinical pregnancy outcome.