Analysis Of Detection Rate And Influencing Factors Of Cervical Intraepithelial Neoplasia In Shanxi And Inner Mongolia

Objective:To investigate the different detection rates and influencing factors of cervical intraepithelial neoplasia between Shanxi Province and Inner Mongolia autonomous region.Methods:During the period from June 2014 to December 2014,40,000 community on-site populations eligible for Shanxi Province(less than 65 married women)and 10,000 community-based populations eligible for conditions(less than 65 married women)in Inner Mongolia Autonomous Region,A total of 50,000 people were surveyed by demographic characteristics,cervical intraepithelial neoplasia and cervical cancer related factors,and cervical cytology screening,Further examination of Human papilloma virus(HPV)typing and colposcopy and pathological examination for atypical squamous cells of undetetmined significance(ASC-US)and above(except for abnormal glandular cells and rejection of colposcopy).The results of the two regional examinations were CIN2(cervical intraepithelial neoplasia II,CIN2)and above as CIN2+ group(237 cases in Shanxi Province,23 cases in Inner Mongolia Autonomous Region),chronic inflammation volunteered into the researcher and all CIN 1 as the control group(2067 cases in Shanxi province,468 cases in Inner Mongolia Autonomous Region),a prospective cohort study was established for a period of 4 years.Baseline data from 2304 women in Shanxi Province and 491 women in the Inner Mongolia autonomous region were cross-sectional analyzed.Logistic regression models were used to analyze risk factors for CIN2+.Results:(1)The detection rate of ASC-US on the community site was higher in Shanxi province than in Inner Mongolia Autonomous Region(5.76% vs.4.72%),and those with abnormal cytology in Shanxi and Inner Mongolia Autonomous Region(ASC-US and above)were 6.94% and 4.72%.(2)The detection rate of CIN in colposcopy in Shanxi Province was higher than that in Inner Mongolia Autonomous Region(2.00% vs.0.66%),and the detection rate of squamous of cervical carcinoma(SCC)was also the same(47.5/100,000 vs.20.0/100,000).The detection rates of CIN2+ in Shanxi Province and Inner Mongolia Autonomous Region were 0.5925% and 0.23%,respectively.(3)HR-HPV infection,previously unknown vaginitis can increase the risk of CIN2+ in both Shanxi and Inner Mongolia Autonomous Region.While the age of menarche is equal or lesser than 16 years old,and the junior high school education are independent risk factors for CIN2+ in Shanxi Province.Menopause is a protective factor for CIN2+ in Shanxi Province.Not cleaning the vulva after sex is a risk factor for CIN2+ in Inner Mongolia Autonomous Region.(4)The top three types of HR-HPV infection in Shanxi and Inner Mongolia Autonomous Region were 16,58 and 52;the top five types of HR-HPV infection in Shanxi CIN2+ group were 16,58,31,52,33,but in Inner Mongolia.Autonomous Region the top five types of HR-HPV infection in the CIN2+ group were 16,33,52,58,and 51.Conclusions:The results suggest that the differences in risk factors between the two regions may explain the difference in the incidence of cervical intraepithelial neoplasia and cervical cancer in Shanxi Province and Inner Mongolia Autonomous Region,HR-HPV distribution and education level,age at menarche,menopause or not,whether to clean vulva after sex life and previous vaginitis are associated with CIN2+,and regional differences in CIN2+ risk factors are closely related to the development of regional-specific prevention strategies.