Analysis Of The Risk Factors Of Recurrence Of Stage IA Adenocarcinoma After Sublobectomy

Objective:sublobectomy can preserve more pulmonary function,with the advantages of less surgical trauma and low incidence of postoperative complications,etc.Currently,more and more patients with early stage of lung cancer adopt this operation,but some patients still experience recurrence after surgery,and the factors affecting the prognosis of patients are still controversial.The purpose of this study was to find out the risk factors of recurrence after sublobectomy in patients with stage IA lung adenocarcinoma,and to provide some basis for patients with stage IA lung adenocarcinoma to choose appropriate treatment.Methods:clinical and pathological data of patients with stage IA lung adenocarcinoma who underwent sublobectomy in the department of thoracic surgery,cancer hospital of Chinese medical college from September 2011 to May 2016 were collected.Factors included gender,age,smoking history,family tumor history,surgical approach,number of lymph nodes removed,lymph node resection,tumor diameter,pathological subtype,degree of differentiation,and surgical compromise.SPSS(V21.0,SPSS)was used for statistical analysis.DFS curves were estimated using the Kaplan-Meier method.Possible prognostic predictors of DFS were analyzed using Cox univariate and multivariate proportional hazards regression.P<0.05 was considered statistically significant.Results:of the 276 patients,13 had postoperative recurrence and metastasis.Among them,6 cases had local recurrence and 7 cases had distant metastasis.COX univariate regression analysis showed that age,tumor diameter,solid component in tumor pathology,degree of differentiation and compromise resection significantly affected DFS.COX multivariate retrospective analysis showed that age,solid components in tumor pathology and degree of differentiation significantly affected DFS.Kaplan-meier survival analysis showed that five factors,including age,tumor diameter,solid component in tumor pathology,degree of differentiation and compromise resection,significantly affected the DFS of patients with stage IA pulmonary adenocarcinoma after sublobectomy.Conclusions:age,presence of solid components in tumor pathology,and degree of tumor differentiation significantly affect DFS after sublobotomy in patients with stage IA lung adenocarcinoma.Patients with stage IA lung adenocarcinoma with>65 years of age,solid components in the tumor,and poorly differentiated adenocarcinoma had lower DFS after sublobectomy.