| Objective:To observe the clinical effect of recombinant human acidic fibroblast growth factor(RHAFGF)combined with kangfuxin liquid in the treatment of radiation oral mucositis in patients with nasopharyngeal carcinomaMethods: According to admission order were randomized method,will be in December 2017 to October 2018 in xiangxi autonomous prefecture people's hospital tumor during a division for the first time and pathological diagnosis of nasopharyngeal carcinoma radiotherapy of 40 patients,according to the inclusion criteria and exclusion criteria were randomly divided into observation group and control group,each group20 cases both set to be regular oral care during radiotherapy,the acrid food,two groups of patients were the first day in radiotherapy dosage control for new rehabilitation group,in a day earlyAfter supper and before going to bed take 10 to 15 ml contains new recovery liquid,each time not less than 3 minutes,medicated administering after half an hour without eating or drinking water group for restructuring of acidic fibroblast growth factor combined rehabilitation new liquid group,on thebasis of the control group at the same time the use of recombinant human acidic fibroblast growth factor of spray,spray 2-3 / times,if appear in the mouth in erosion or ulcer,can spray angles,each ulcer surface spray 2-3daily observation during radiation therapy of the oral mucosa reaction in patients with oral pain,7 days 14 days in radiotherapy 35 th day 21 28 daysOn the 42 nd day and at the end of radiotherapy,two trained physicians in the undergraduate department evaluated the grade of oral mucositis and the degree of pain of the patient,and recorded the patient's weight before and at the end of radiotherapy.Patients were asked to complete a quality of life score before and after radiotherapy.Results:1.Comparison of general data between the observation group and the control group showed no statistically significant difference(P >0.05).2.At the end of radiotherapy on day 7,day 14,day 35 and day 42,there was no significant difference in the incidence of RIOM between the observation group and the control group(P>0.05).At day 21 and day 28,the incidence of RIOM in the observation group was lower than that in the control group,and the difference was statistically significant(P <0.05).3.The time of initial RIOM occurrence between the two groups was later in the observation group than in the control group,and the difference was statistically significant(P<0.05).4.On the 7th and 14 th days of radiotherapy,RIOM grading of the observation group and the control group was compared,and the difference was not statistically significant(P > 0.05).At the end of the21 st day,28 th day,35 th day,42 nd day and radiotherapy,the severity ofRIOM in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).5.On day 7 and day 14,there was no significant difference in pain scores between the observation group and the control group(P>0.05).At the end of day 21,28,35,42 and radiotherapy,the degree of pain in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).6.Before radiotherapy,there was no significant difference in body weight between the observation group and the control group(P>0.05).After radiotherapy,the weight loss of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).7.In terms of quality of life,there was no significant difference in scores between the observation group and the control group before radiotherapy(P > 0.05).After radiotherapy,the observation group was superior to the control group in terms of total health status of emotional function,fatigue,pain,nausea,vomiting,loss of appetite and insomnia,and the difference was statistically significant(P<0.05).However,there was no significant difference between the two groups in the field of physical function,role function,cognitive function,social function,breathlessness,diarrhea,constipation and economic difficulties(P <0.05).conclusion:Recombinant human acidic fibroblast growth factor combined rehabilitation new liquid to a certain extent,reduce the incidence of inflammation of radioactive oral cavity mucous membrane,delays theonset of inflammation of radioactive oral cavity mucous membrane,reduce the severity of the oral cavity mucous membrane inflammation and pain,for the prevention and treatment of radioactive oral cavity mucositis has good curative effect,clinical popularization value... |
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