| ObjectiveIn this study,the radiotherapy-induced oral mucositis in patients with head and neck malignant tumors was intervened by holding kangfuxin buccal ice cube in mouth.The aim of this study was to investigate the effects of kangfuxin buccal ice cube on the incidence,occurrence location,occurrence time,severity of radiotherapy-induced oral mucositis,as well as the pain intensity during radiotherapy.MethodThis study was a quasi-experimental study using convenient sampling method.A total of 188 patients who received regular radiotherapy and met the inclusion criteria were selected from December 2015 to January 2017 in the Department of Radiation Oncology,one of the top three hospitals in Qingdao.Patients were divided into control group(94patients from December 2015 to May 2016)and observation group(94 patients from June2016 to January 2017)according to hospitalization time.The control group received routine oral care,patients were asked to gargle a 10 ml solution of kangfuxin for three minutes after daily breakfast,lunch,dinner,and then to swallow slowly.Patients enrolled into the observation group,on the basis of routine oral care,were instructed to hold a kangfuxin buccal ice cube in their mouth at 10 minutes before and after radiotherapy respectively,the ice cube volume was 15ml,one piece at a time,and then to swallow as the ice melted.The severity of radiotherapy-induced oral mucositis and the pain intensity were evaluated according to Classification criteria for acute radiation mucosal reaction(RTOG),Numeric Pain Rating Scale,occurrence time,occurrence location of radiotherapy-induced oral mucositis and other general data were collected with a self-designed questionnaire.During the study period,the same kind of additional drugs were used in both two groups if the radioactive oral mucosal injury was severe.All collected data were statistically analyzed using the SPSS 19.0 programs.Results1.There were no significant differences in sex,age,weight,dose of radiotherapy,education level,type of disease and other general data between two groups(P>0.05).2.The incidence of radiotherapy-induced oral mucositis in the observation group was lower than the control group,the difference was statistically significant(c~2=25.061,(49)=0.01).3.The difference in the severity of radiotherapy-induced oral mucositis between the two groups was statistically significant when the dose of radiotherapy was less than 60GY(P<0.05),but no significant difference at radiation therapy doses of more than 60GY(P>0.05).4.Radiotherapy-induced oral mucositis occurred later in the observation group than the control group,the differences were statistically significant when the oral mucosal injury was grade 1,grade 2,grade 3(P<0.05),but no significant difference at grade 4(t=0.773,P=0.459).5.The level of Pain in observation group was lower than the control group,the difference was statistically significant(Z=3.812,P=0.001).6.The difference in predilection site of radiotherapy-induced oral mucositis between the two groups was not statistically significant(c2=0.957,P=0.996).7.The needs for additional drugs in observation group was lower than the control group,the difference was statistically significant(c~2=12.018,(49)=0.001).ConclusionGargling kangfuxin liquid routinely and holding kangfuxin buccal ice cube in mouth both have a certain effect for preventing and treating radiotherapy-induced oral mucositis,and the kangfuxin buccal ice cube is better.Holding kangfuxin buccal ice cube in mouth can delay the occurrence time of radiotherapy-induced oral mucositis to a certain extent,reduce the incidence and severity,relieve the pain level of patients,prompt a smooth radiotherapy plan,and the safety is good,no drug-related adverse reactions was found in this study.It is worthy of further study and development in clinical. |
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